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Immunity：自噬助力免疫细胞分化

2017-09-18 海北 MedSci原创

自噬免疫代谢
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嗜中性粒细胞是一种重要的，寿命较短的先天性免疫介质。其需要不断的补充。嗜中性粒细胞在骨髓中的分化涉及广泛的细胞质和细胞核的重塑。但是至今为止，这些耗能变化是如何被管理的依旧是未知的。已有的研究表明，自噬在其他血细胞谱系的分化中起着不可或缺的作用，但是至今，其在粒细胞生成过程中的功能还没有完全被研究透彻。

嗜中性粒细胞是一种重要的，寿命较短的先天性免疫介质。其需要不断的补充。嗜中性粒细胞在骨髓中的分化涉及广泛的细胞质和细胞核的重塑。但是至今为止，这些耗能变化是如何被管理的依旧是未知的。已有的研究表明，自噬在其他血细胞谱系的分化中起着不可或缺的作用，但是至今，其在粒细胞生成过程中的功能还没有完全被研究透彻。 来自牛津大学的研究人员发现，在体内，细胞代谢和自噬是在发育过程中被规划的，其对于嗜中性粒细胞的分化起着至关重要的作用。缺乏Atg7，一种关键自噬蛋白，的嗜中性粒细胞前体细胞具有增强的糖酵解活性，线粒体呼吸受损，ATP的产生减少，并伴随着脂滴的积累。抑制自噬介导的脂质的降解或是脂肪酸的氧化就足够引起嗜中性粒细胞分化的缺陷。相反，在细胞自噬缺陷的嗜中性粒细胞前体细胞中注入脂肪酸或是丙酮酸，促进线粒体呼吸，可以挽救其分化能力。 因此，研究人员的结果显示，自噬介导了脂肪的分解，提供游离的脂肪酸，以支持线粒体呼吸途径，而线粒体呼吸对于嗜中性粒细胞的分化是必须的。 原始出处： Riffelmacher T et al. Autophagy-Dependent Generation of Free

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    2024-03-29 普外科医师 来自浙江省

    签到学习

    0

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    2018-08-12 12498d2fm51(暂无昵称)

    #Immunity#

    0

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    2017-10-26 耐看

    签到学习了

    0

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    2017-10-13 杨柳青青

    签到学习了--

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2196003, encodeId=7cb52196003c1, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=4, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85f65311925, createdName=普外科医师, createdTime=Fri Mar 29 09:27:32 CST 2024, time=2024-03-29, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2030360, encodeId=a916203036016, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sun Aug 12 21:42:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256084, encodeId=715c256084ba, content=签到学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/18/138869a51881d5301c1c6d241373ddfa.jpg, createdBy=f89b1930658, createdName=耐看, createdTime=Thu Oct 26 09:44:13 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252502, encodeId=92aa25250276, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Fri Oct 13 09:11:21 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249742, encodeId=12e0249e42e1, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Oct 02 20:23:22 CST 2017, time=2017-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249436, encodeId=3564249436e8, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Oct 01 15:32:39 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249200, encodeId=b610249200ae, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sat Sep 30 23:11:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248580, encodeId=a22e24858098, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Sep 28 21:04:13 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248173, encodeId=77c02481e379, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Sep 27 12:02:34 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247951, encodeId=005c24e951b7, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Sep 26 20:08:49 CST 2017, time=2017-09-26, status=1, ipAttribution=)]
    2017-10-02 杨柳青青

    签到学习了--

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2196003, encodeId=7cb52196003c1, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=4, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85f65311925, createdName=普外科医师, createdTime=Fri Mar 29 09:27:32 CST 2024, time=2024-03-29, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2030360, encodeId=a916203036016, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sun Aug 12 21:42:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256084, encodeId=715c256084ba, content=签到学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/18/138869a51881d5301c1c6d241373ddfa.jpg, createdBy=f89b1930658, createdName=耐看, createdTime=Thu Oct 26 09:44:13 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252502, encodeId=92aa25250276, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Fri Oct 13 09:11:21 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249742, encodeId=12e0249e42e1, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Oct 02 20:23:22 CST 2017, time=2017-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249436, encodeId=3564249436e8, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Oct 01 15:32:39 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249200, encodeId=b610249200ae, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sat Sep 30 23:11:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248580, encodeId=a22e24858098, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Sep 28 21:04:13 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248173, encodeId=77c02481e379, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Sep 27 12:02:34 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247951, encodeId=005c24e951b7, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Sep 26 20:08:49 CST 2017, time=2017-09-26, status=1, ipAttribution=)]
    2017-10-01 杨柳青青

    签到学习了--

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2196003, encodeId=7cb52196003c1, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=4, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85f65311925, createdName=普外科医师, createdTime=Fri Mar 29 09:27:32 CST 2024, time=2024-03-29, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2030360, encodeId=a916203036016, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sun Aug 12 21:42:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256084, encodeId=715c256084ba, content=签到学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/18/138869a51881d5301c1c6d241373ddfa.jpg, createdBy=f89b1930658, createdName=耐看, createdTime=Thu Oct 26 09:44:13 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252502, encodeId=92aa25250276, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Fri Oct 13 09:11:21 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249742, encodeId=12e0249e42e1, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Oct 02 20:23:22 CST 2017, time=2017-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249436, encodeId=3564249436e8, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Oct 01 15:32:39 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249200, encodeId=b610249200ae, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sat Sep 30 23:11:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248580, encodeId=a22e24858098, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Sep 28 21:04:13 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248173, encodeId=77c02481e379, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Sep 27 12:02:34 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247951, encodeId=005c24e951b7, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Sep 26 20:08:49 CST 2017, time=2017-09-26, status=1, ipAttribution=)]
    2017-09-30 杨柳青青

    签到学习了--

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2196003, encodeId=7cb52196003c1, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=4, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85f65311925, createdName=普外科医师, createdTime=Fri Mar 29 09:27:32 CST 2024, time=2024-03-29, status=1, ipAttribution=浙江省), GetPortalCommentsPageByObjectIdResponse(id=2030360, encodeId=a916203036016, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sun Aug 12 21:42:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256084, encodeId=715c256084ba, content=签到学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/18/138869a51881d5301c1c6d241373ddfa.jpg, createdBy=f89b1930658, createdName=耐看, createdTime=Thu Oct 26 09:44:13 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252502, encodeId=92aa25250276, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Fri Oct 13 09:11:21 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249742, encodeId=12e0249e42e1, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Oct 02 20:23:22 CST 2017, time=2017-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249436, encodeId=3564249436e8, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Oct 01 15:32:39 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249200, encodeId=b610249200ae, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sat Sep 30 23:11:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248580, encodeId=a22e24858098, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Sep 28 21:04:13 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248173, encodeId=77c02481e379, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Sep 27 12:02:34 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247951, encodeId=005c24e951b7, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Sep 26 20:08:49 CST 2017, time=2017-09-26, status=1, ipAttribution=)]
    2017-09-28 杨柳青青

    签到学习了--

    0

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    2017-09-27 杨柳青青

    签到学习了--

    0

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    2017-09-26 杨柳青青

    签到学习了--

    0

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