Dig Liver Dis:选择性EVL并非肝硬化患者发生细菌感染的风险因素

2018-01-20 MedSci 国际肝病

肝硬化患者发生细菌感染的风险增加,通常认为介入性操作可增加这一易感性。

肝硬化患者发生细菌感染的风险增加,通常认为介入性操作可增加这一易感性。意大利墨西拿大学医院Maimone等近日完成的一项研究表明,肝硬化患者接受选择性内镜下曲张静脉套扎术(EVL)后,细菌感染的发生率很低,不需要应用抗生素预防性治疗。

该项研究纳入总共接受112例次选择性EVL操作的60例连续性肝硬化患者,每次操作应用1~7个皮圈,直至静脉曲张根除,在EVL之前和24小时后,进行炎症/感染标志物检测和血液培养,对接受选择性EVL肝硬化患者的细菌感染发生率进行评估。

结果,患者肝硬化的病因包括代谢性27例(45%)、病毒性21例(35%)和酒精性12例(20%),Child-Pugh A/B/C级分别为29/26/5例,23例(38%)患者合并腹水,15例(25%)患者合并肝细胞癌。EVL之前,所有患者的血液培养均为阴性,EVL后,3/112例次(2.7%)细菌培养阳性,1例患者分离出缓症链球菌,2例患者分离出表皮葡萄球菌,这3例患者中,无一例发生临床相关的感染特征,表明细菌培养阳性只是一过性菌血症,并未导致临床后果。

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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 21 08:12:02 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-28 明崖

    学习了.有好处

    0

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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 21 08:12:02 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-24 jihuaijun1112

    学习学习学习

    0

  5. 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  6. 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    2018-01-21 hhh678

    henhao

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jan 21 09:01:33 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280573, encodeId=cf602805e374, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Jan 21 08:24:59 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280563, encodeId=3e0728056381, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 21 08:12:02 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-21 龙胆草

    学习谢谢分享

    0

  8. 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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 21 08:12:02 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-21 明月清辉

    谢谢分享.学习了

    0

  9. 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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 21 08:12:02 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-21 sunfeifeiyang

    0

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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jan 21 08:12:02 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-21 Y—xianghai

    学习了新知识

    0