Retina:TREFOIL因子家族1表达可能作为视网膜母细胞瘤患者的临床观察的生物标志物!

2017-10-19 cuiguizhong MedSci原创

德国埃森杜伊斯堡 - 埃森大学医学院解剖学研究所神经解剖学系的Busch M近日在Retina杂志上发表了他们近期的一项工作,他们研究了三叶因子家族1(TFF1)在视网膜母细胞瘤中的表达与不同临床参数的相关性,来评估TFF1在肿瘤发生发展中的潜在作用。


德国埃森杜伊斯堡 - 埃森大学医学院解剖学研究所神经解剖学系的Busch M近日在Retina杂志上发表了他们近期的一项工作,他们研究了三叶因子家族1(TFF1)在视网膜母细胞瘤中的表达与不同临床参数的相关性,来评估TFF1在肿瘤发生发展中的潜在作用。

具体的试验方法是,通过免疫染色和实时荧光定量PCR的方法,分析来自视网膜母细胞瘤患者的59例摘除眼睛的样品,观察其TFF1表达情况。三叶因子家族1表达诸多因素有关,如人口统计学、转移情况、肿瘤淋巴结转移时期、视网膜母细胞瘤国际分类、肿瘤分化水平和治疗等。

根据他们的分析,TFF1表达在大龄儿童的单侧肿瘤、分化不良的肿瘤和较高的肿瘤淋巴结转移阶段中显着上调。因此,这项回顾性研究显示,在较高的临床肿瘤转移期和分化不良的肿瘤细胞中,单侧肿瘤的TFF1水平明显高于较低转移阶段、肿瘤分化程度较高的肿瘤。此外,TFF1表达情况与诊断时患者的年龄相关。他们的数据表明,TFF1表达水平是视网膜母细胞瘤患者肿瘤分期和预后分类中潜在有用的另一种生物标志物。

原文出处:

Busch, M., et al., TREFOIL FACTOR FAMILY 1 EXPRESSION CORRELATES WITH CLINICAL OUTCOME IN PATIENTS WITH RETINOBLASTOMA. Retina, 2017.

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createdName=zhangj7108, createdTime=Fri Mar 30 17:10:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772244, encodeId=e10e1e722447d, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Thu Sep 13 13:10:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1913846, encodeId=ac60191384620, content=<a href='/topic/show?id=4684153e41f' target=_blank style='color:#2F92EE;'>#RET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15374, encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 08 09:10:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921040, encodeId=eaa1192104098, content=<a href='/topic/show?id=f9af13291a4' target=_blank style='color:#2F92EE;'>#Oil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13291, encryptionId=f9af13291a4, topicName=Oil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Oct 02 21:10:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793297, encodeId=fc5b1e9329782, content=<a href='/topic/show?id=5400153e639' target=_blank style='color:#2F92EE;'>#Retina#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15376, encryptionId=5400153e639, topicName=Retina)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d342500153, createdName=12498bf3m25暂无昵称, createdTime=Tue Sep 18 17:10:00 CST 2018, time=2018-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796363, encodeId=0d0b1e963635b, content=<a href='/topic/show?id=848c1e785a5' target=_blank style='color:#2F92EE;'>#trefoil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17785, encryptionId=848c1e785a5, topicName=trefoil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ab72500038, createdName=124985dbm06(暂无昵称), createdTime=Tue Sep 11 05:10:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269959, encodeId=9e9a1269959e2, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475853, encodeId=eb5414e585375, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560670, encodeId=1a5915606e002, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2018-02-08 ysjykql
  5. [GetPortalCommentsPageByObjectIdResponse(id=1841117, encodeId=b531184111ec6, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu May 03 08:10:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941606, encodeId=9538194160676, content=<a href='/topic/show?id=c9752300260' target=_blank style='color:#2F92EE;'>#临床观察#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23002, encryptionId=c9752300260, topicName=临床观察)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, 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encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 08 09:10:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921040, encodeId=eaa1192104098, content=<a href='/topic/show?id=f9af13291a4' target=_blank style='color:#2F92EE;'>#Oil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13291, encryptionId=f9af13291a4, topicName=Oil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Oct 02 21:10:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793297, encodeId=fc5b1e9329782, content=<a href='/topic/show?id=5400153e639' target=_blank style='color:#2F92EE;'>#Retina#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15376, encryptionId=5400153e639, topicName=Retina)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d342500153, createdName=12498bf3m25暂无昵称, createdTime=Tue Sep 18 17:10:00 CST 2018, time=2018-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796363, encodeId=0d0b1e963635b, content=<a href='/topic/show?id=848c1e785a5' target=_blank style='color:#2F92EE;'>#trefoil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17785, encryptionId=848c1e785a5, topicName=trefoil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ab72500038, createdName=124985dbm06(暂无昵称), createdTime=Tue Sep 11 05:10:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269959, encodeId=9e9a1269959e2, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475853, encodeId=eb5414e585375, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560670, encodeId=1a5915606e002, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2018-10-02 智慧医人
  6. [GetPortalCommentsPageByObjectIdResponse(id=1841117, encodeId=b531184111ec6, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu May 03 08:10:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941606, encodeId=9538194160676, content=<a href='/topic/show?id=c9752300260' target=_blank style='color:#2F92EE;'>#临床观察#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23002, encryptionId=c9752300260, topicName=临床观察)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, 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encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 08 09:10:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921040, encodeId=eaa1192104098, content=<a href='/topic/show?id=f9af13291a4' target=_blank style='color:#2F92EE;'>#Oil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13291, encryptionId=f9af13291a4, topicName=Oil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Oct 02 21:10:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793297, encodeId=fc5b1e9329782, content=<a href='/topic/show?id=5400153e639' target=_blank style='color:#2F92EE;'>#Retina#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15376, encryptionId=5400153e639, topicName=Retina)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d342500153, createdName=12498bf3m25暂无昵称, createdTime=Tue Sep 18 17:10:00 CST 2018, time=2018-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796363, encodeId=0d0b1e963635b, content=<a href='/topic/show?id=848c1e785a5' target=_blank style='color:#2F92EE;'>#trefoil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17785, encryptionId=848c1e785a5, topicName=trefoil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ab72500038, createdName=124985dbm06(暂无昵称), createdTime=Tue Sep 11 05:10:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269959, encodeId=9e9a1269959e2, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475853, encodeId=eb5414e585375, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560670, encodeId=1a5915606e002, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1841117, encodeId=b531184111ec6, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu May 03 08:10:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941606, encodeId=9538194160676, content=<a href='/topic/show?id=c9752300260' target=_blank style='color:#2F92EE;'>#临床观察#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23002, encryptionId=c9752300260, topicName=临床观察)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, 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  8. 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href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475853, encodeId=eb5414e585375, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560670, encodeId=1a5915606e002, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat Oct 21 13:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 zutt
  9. 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Cancer:视网膜母细胞瘤幸存者的视力和生活质量情况(随访42年)

发表在Cancer的一项新近研究针对青年时罹患视网膜母细胞瘤的民众进行了调查。 美国视网膜母细胞瘤患者的存活率非常高,5年存活率约为97%。然而,很少有人知道视网膜母细胞瘤患者未来的患病情况和幸福感。 由于既往关于视网膜母细胞瘤幸存者的晚年健康状况的相关研究样本量和范围有限,因此医务人员获得的相关知识非常有限。 纪念斯隆凯特林癌症中心的研究人员决定扩大样本量,以探究幸存者的生活质量及幸福感。视网膜

Oncotarget:异黄酮具有抗视网膜母细胞瘤的作用

视网膜母细胞瘤是一种来源于光感受器前体细胞的恶性肿瘤,是婴幼儿最常见的眼内恶性肿瘤,成人中罕见。具有家族遗传倾向,临床表现复杂,易发生颅内及远处转移,常危及患儿生命,早发现、早诊断及早治疗是提高治愈率、降低死亡率的关键。

Eur Radiol:晚期视网膜母细胞瘤在常规MRI结合扩散加权成像和组织病理学结果的相关性

在婴幼儿眼病中,是性质最严重、危害性最大的一种恶性肿瘤视网膜母细胞瘤(retinoblastoma,RB)是婴幼儿最常见的眼内恶性肿瘤,对视力和生命有严重的威胁和危害。发生于视网膜核层,具有家族遗传倾向,多发生于5岁以下,可单眼、双眼先后或同时罹患,本病易发生颅内及远处转移,常危及患儿生命,因此早期发现,早期诊断及早期治疗是提高治愈率、降低死亡率的关键。本研究为了验证常规MRI发现晚期眼内视网膜母