ARTIF ORGANS:3D打印人工心脏获得巨大进步 能跳动45分钟

2017-07-19 贾朝娟 环球医学

心脏移植是拯救终末期心脏病患者的重要手段,但移植心脏来源的稀缺限制了这一技术的广泛应用。近日,瑞士的苏黎世联邦理工学院功能材料实验室的研究团队3D打印了一种人工心脏。这种人造心脏“在形状和功能上”非常接近真实的器官。虽然近期内不能像真实心脏一样工作,但是这项成果暗示了未来人们有望开发并应用更小的、与人类器官更相近的人造器官。



心脏移植是拯救终末期心脏病患者的重要手段,但移植心脏来源的稀缺限制了这一技术的广泛应用。近日,瑞士的苏黎世联邦理工学院功能材料实验室的研究团队3D打印了一种人工心脏。这种人造心脏“在形状和功能上”非常接近真实的器官。虽然近期内不能像真实心脏一样工作,但是这项成果暗示了未来人们有望开发并应用更小的、与人类器官更相近的人造器官。

根据研发人员Nicholas Cohrs的说法,它是由硅树脂制成的,重量是390克,比正常的心脏要多80克,而且包含了一个“复杂的内部结构”。模仿真实的人类心脏,这个模拟的心脏包含右心室和左心室,并通过3D打印技术成型。

人类心脏的左、右心室间存在室间隔,其大部分为心肌。该人工心脏也有一个中央腔,在外部泵作用下可以膨胀收缩,以起到类似于肌肉的作用。除了需要外部驱动,该人工心脏还有一个更大的缺点,即寿命太短。根据研究团队报道的成果,该硅胶心脏跳动3000次后就会开始衰减,相当于只能使用大约45分钟,因此无法应用于临床植入,这在实践中几乎没有用。虽然开发人员并没有打算让这个模型立即成为一种临时植入物,但它已经为人工器官的思考铺平了道路。

“这只是一项可行性测试。Cohrs说:“我们的目标不是为植入的心脏做好准备,而是为人工心脏的发展提供一个新的方向。尽管如此,该人造装置预示了在未来创造更好的人工心脏的可能性。只不过,制造全新的人造生物器官仍有很长的一段路。

全世界约有2600万人罹患心脏衰竭,而这项新技术可能会缩小需求与供者之间的差距。

原始出处:Nicholas H. Cohrs, Anastasios Petrou, Michael Loepfe, et al. A Soft Total Artificial Heart—First Concept Evaluation on a Hybrid Mock Circulation. Artificial Organs. 10 July 2017

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    2017-07-23 lou.minghong

    3D打印很强大!

    0

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    2017-07-21 zhaojie88
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