ROS1阳性非小细胞肺癌诊断病理专家共识

2018-04-20 中国抗癌协会肿瘤病理专业委员会 中华病理学杂志,2018,47(4) :248-251.

准确的分子靶标检测是NSCLC患者获取靶向治疗的前提。与ALK融合基因检测类似,目前针对ROS1融合基因的常用方法有3种:FISH、RT-PCR和免疫组织化学法。上述3种方法各有其优缺点。FISH方法为美国国家综合癌症网络(NCCN)指南推荐的检测ROS1融合基因的检测方法,但价格昂贵,操作规范要求较高,目前还没有一家公司的FISH获得FDA的批准;RT-PCR对标本质量要求较高,需专用的试剂盒进

中文标题:

ROS1阳性非小细胞肺癌诊断病理专家共识

发布日期:

2018-04-20

简要介绍:

准确的分子靶标检测是NSCLC患者获取靶向治疗的前提。与ALK融合基因检测类似,目前针对ROS1融合基因的常用方法有3种:FISH、RT-PCR和免疫组织化学法。上述3种方法各有其优缺点。FISH方法为美国国家综合癌症网络(NCCN)指南推荐的检测ROS1融合基因的检测方法,但价格昂贵,操作规范要求较高,目前还没有一家公司的FISH获得FDA的批准;RT-PCR对标本质量要求较高,需专用的试剂盒进行检测,目前国内已有多个试剂盒获CFDA批准;免疫组织化学简便易行,但阳性标准不统一,有一定的假阳性。由于ROS1融合基因型肺癌发病率低,在临床实践中,怎样有效规范地应用现有的检测体系,最大化地筛选出ROS1阳性的患者,是ROS1阳性患者获得靶向药物治疗的关键。基于这些因素,协作组结合多中心的试验数据和国内外已报道的研究成果,讨论适合我国国情的ROS1阳性NSCLC检测方法,并达成专家共识。

 

拓展指南:非小细胞肺癌相关指南:

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    2018-05-17 hanmeijinxiu

    学习了.谢谢分享

    0

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    2018-04-26 清风拂面

    谢谢分享学习

    0

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    2018-04-26 1e1b8538m79(暂无匿称)

    不错的文章值得拥有.

    0

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    2018-04-26 wqkm

    ^_^^_^^_^

    0