Clinical Gastroenterology H:人种差异和胰腺癌发病率和死亡率的关系

2019-12-27 不详 MedSci原创

胰腺癌是美国发病率不断上升的癌症之一。目前关于种族差异与发病率和死亡率之间的关系知之甚少。因此,本项研究对不同地区,不同时期,不同年龄段和不同疾病阶段胰腺癌的发病率和死亡率进行了种族差异分析。

背景与目标
胰腺癌是美国发病率不断上升的癌症之一。目前关于种族差异与发病率和死亡率之间的关系知之甚少。因此,本项研究对不同地区,不同时期,不同年龄段和不同疾病阶段胰腺癌的发病率和死亡率进行了种族差异分析。

方法
研究人员从2001年至2015年的国家癌症登记局获得了全美胰腺癌发生率的数据,这些数据涉及所有50个州和州的发病率,人口统计学及肿瘤特征。研究人员分别按白人和黑人患者的10岁年龄段(30-39岁到70-79岁以及80岁或以上)绘制发病率。我们针对年龄和种族类别计算了95%CI的发生率和死亡率比率。

结果
从2001年到2015年,黑人与白人患者的胰腺癌发病率和死亡率差异在5年内有所降低。但是,在2001年至2015年的所有年龄组中,黑人的胰腺癌发病率和死亡率高于白人(发生率,24.7 vs 19.4 / 10万; IRR为1.28;95%CI为1.26-1.29;死亡率为23.3 vs 18.4 / 10万;IRR为1.27; 95%CI为1.26-1.28)。年龄较小的白人和黑人的发病率增加,并且在30-39岁的人群中发病率最高。从2001年到2015年,年轻白人的发病率增加了57%(IRR,1.70; 95%CI,1.43-2.02),黑人的发病率增加了44%(IRR,1.47; 95%CI,1.01-2.15)。

结论
在美国,胰腺癌的发病率和死亡率存在种族差异,随地区,患者年龄和癌症阶段的不同而不同。

原始出处:

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    2020-07-17 许安
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    2019-12-29 zll0628