Heart:心内膜炎幸存者瓣膜反流及随后发生心力衰竭的风险

2019-12-11 xing.T MedSci原创

由此可见,在接受药物治疗的IE幸存者中,严重或中度左侧瓣膜反流患者HF的风险明显高于IE出院时无反流的患者。需要对这些患者进行严密监视以及时进行手术。

原发性瓣膜感染性心内膜炎(IE)幸存者常发生明显的瓣膜反流,但与IE出院后发生心力衰竭(HF)风险之间的相关性很少描述。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员链接了东丹麦心内膜炎登记中心2002年至2016年的数据,其中包括接受IE药物治疗且存活的患者。

IE出院时通过超声心动图评估左侧瓣膜反流情况,并评估了HF的纵向风险。研究人员采用多变量校正Cox分析法评估了有反流(中度或重度)与没有反流患者发生心力衰竭的相关风险。

研究人员纳入了192例患者,87例出院时存在反流症状(30例主动脉瓣反流和57例二尖瓣反流),105例患者没有反流。IE出院时出现反流的患者在随访5年内HF累积风险为28.7%,而没有反流的患者为12.4%。相应的多变量调整后HR为3.53(95%CI为1.72至7.25)。研究人员发现,与无瓣膜反流的患者相比,主动脉瓣反流(HR=2.91,95%CI为1.14至7.43)和二尖瓣反流(HR=3.95,95%CI为1.80至8.67)患者的心衰风险增加。在随访期间,有或没有反流的患者中分别有21.9%和5.7%的患者接受了左侧瓣膜手术。

由此可见,在接受药物治疗的IE幸存者中,严重或中度左侧瓣膜反流患者HF的风险明显高于IE出院时无反流的患者。需要对这些患者进行严密监视以及时进行手术。 

原始出处:

Lauge Østergaard.et al.Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure.heart.2019.http://dx.doi.org/10.1136/heartjnl-2019-315715

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    2019-12-13 zhaojie88
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    2019-12-13 slcumt
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    2019-12-13 feifers
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    2019-12-11 拿着枪的小啰啰

    学习了

    0

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