Nat Commun:“以形补形”:多吃草莓、石榴,预防肠道疾病!

2019-01-12 佚名 中国生物技术网

肠道菌群在人体健康和病理生理学中的重要性是无可争辩的,尽管有丰富的宏基因组学数据支撑,但其在人类健康和疾病中的功能仍然是个巨大的谜团。

肠道菌群在人体健康和病理生理学中的重要性是无可争辩的,尽管有丰富的宏基因组学数据支撑,但其在人类健康和疾病中的功能仍然是个巨大的谜团。

已知来自石榴、草莓等浆果果实中的尿石素A(UroA)是一种主要微生物代谢产物,它具有抗炎、抗氧化和抗衰老的作用。近日,美国路易斯维尔大学(UofL)的研究人员发现,UroA能够减轻并预防炎症性肠病(IBD)。目前,全世界有数百万人患有溃疡性结肠炎或克罗恩氏病等IBD,但几乎没有长期有效治疗方法。

UofL的研究人员已经确定,UroA及其强效合成类似物(UAS03)通过增加某些蛋白质来减轻IBD。这些蛋白质可以收紧肠道中的上皮细胞连接并减少动物模型中的肠道炎症。肠道屏障的紧密连接能防止引起IBD炎症特征的有害微生物和毒素渗透。1月9日在《Nature Communications》上发表的一项临床前研究表明,UroA和UAS03可以减轻炎症并修复肠道屏障完整性的机制还能预防结肠炎。

研究第一作者、博士后研究员Rajbir Singh说:“到目前为止,该领域的普遍观点是UroA通过其抗炎和抗氧化特性发挥益处。我们首次发现它们的功能模式还包括修复肠道屏障功能异常和保持肠道屏障完整性。”



来源:《Nature Communications》

研究通讯作者、微生物学和免疫学助理教授Venkatakrishna Rao Jala博士及其他研究人员一直在研究人类肠道微生物组的代谢产物如何影响健康的方方面面。通过理解特定代谢物的作用,他们希望使用其直接作为治疗疾病的手段。

过去有报告称,肠道中的假链双歧杆菌INIA P815具有从鞣花酸(EA)产生UroA的能力,EA是一种在浆果中发现的化合物。即使食用含有EA的食物,但UroA水平的变化可能是由于从一个个体到另一个个体产生UroA不同菌群的结果,并且一些个体中可能根本没有这种细菌。

虽然通过食用适当的食物并保护有益菌群有助于促进肠道中自然水平的UroA对健康应该有积极的影响,但研究人员认为,使用更稳定的合成UAS03可能在急性结肠炎的病例中具有治疗效果。这需要进一步实验和临床测试来验证这一观点。

Jala说:“我们肠道中的微生物已经进化得能在肠道屏障附近产生有益的代谢产物。然而,这需要我们保护好肠道有益菌并保持健康饮食。这项研究表明,直接食用UroA或类似物可以弥补缺乏负责产生UroA的特定细菌。”

研究合作者、微生物学和免疫学教授Haribabu Bodduluri博士说,该研究的另一项重要发现是UroA和UAS03都显示出具有治疗和保护作用,在结肠炎发生后使用UroA/UAS03能够逆转疾病症状,而在结肠炎发生之前使用UroA/UAS03则可以防止疾病发生。

原始出处:
Rajbir Singh, Sandeep Chandrashekharappa, Sobha R. Bodduluri, et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nature Communications. Jan 9, 2019.

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    2019-03-21 liye789132251
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    2019-09-17 liuli5079
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    2019-01-14 wgsun
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    2019-01-12 lovetcm

    中医石榴皮有收涩作用,可以用于克隆病

    0

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