Sci Transl Med:心肌梗死后输送的高密度脂蛋白增加小鼠心脏葡萄糖摄取和功能。

2017-10-18 MedSci MedSci原创

保护心脏是急性冠状动脉综合征后支持心脏恢复并防止进展为心力衰竭的关键治疗目标。在局部缺血后的早期,心肌细胞主要依赖糖酵解存活时,靶向增加心脏葡萄糖代谢是一个潜在的治疗策略。

保护心脏是急性冠状动脉综合征后支持心脏恢复并防止进展为心力衰竭的关键治疗目标。在局部缺血后的早期,心肌细胞主要依赖糖酵解存活时,靶向增加心脏葡萄糖代谢是一个潜在的治疗策略。

基于作者之前的研究:高密度脂蛋白(HDL)能够调节骨骼肌葡萄糖代谢的结论。作者目前的研究证明:在心肌缺血后输送单剂量的重组HDL(rHDL)可增加心脏葡萄糖摄取,降低梗塞面积,并改善心脏重塑,这些改变与小鼠心功能恢复增强有关。

这些发现同样适用于代谢正常和胰岛素抵抗小鼠。紧接着,研究者在再灌注的15分钟内,通过Akt信号通路进一步验证了HDL对心肌细胞葡萄糖摄取,糖酵解和葡萄糖氧化的直接作用。

这些数据支持在实施经皮介入治疗时使用不溶性HDL制剂来治疗急性冠状动脉综合征的可行性。

原始出处:

Heywood SE, Richart AL。et al.High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice.Sci Transl Med. 2017 Oct 11;9(411). pii: eaam6084. doi: 10.1126/scitranslmed.aam6084.

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    2018-08-22 bsmagic9140
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    2017-10-20 仁心济世

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