Circulation:心脏缺陷患儿的母亲发生心血管疾病的长期风险更高!

2018-04-02 xing.T MedSci原创

由此可见,生出先天性心脏缺陷婴儿的妇女在以后的生活中发生心血管住院的风险更大。子代先天性心脏病可能是心血管疾病易感性的早期标志。

子代先天性心脏病与母亲心血管疾病易感性之间的可能性尚未被研究。近日,心血管领域权威杂志Circulation上发表了一篇研究文章,研究人员的目的是明确生产出先天性心脏病患儿的妇女后期生命中心血管疾病的风险是否更高。

研究人员对1989年至2013年期间在加拿大魁北克分娩的1084251名妇女进行了队列研究。研究人员确定了患有严重、非严重和无心脏缺陷的妇女,并随访这些女性受试者至心血管疾病住院,后延长随访至妊娠后25年。研究人员计算了每1000人每年的心血管住院率,并用Cox比例风险回归估计婴儿心脏缺陷与母亲心血管住院风险之间的风险比和95%可信区间(CIs)。对模型的年龄、胎次、先兆子痫、合并症、物质剥夺和时间段进行了调整。

研究人员发现生出心脏缺陷患儿的妇女心血管总体住院率较高。生出严重心脏缺陷患儿的妇女心血管住院率为每1000人每年3.38例(95%CI为2.67-4.27),非严重心脏缺陷患儿的妇女心血管住院率为每1000人每年3.19例(95%CI为2.96-3.45),而无心脏缺陷患儿的妇女心血管住院率为每1000人每年2.42例(95%CI为2.39-2.44)。在调整后的模型中,与没有生出心脏缺陷患儿的妇女比较,生出严重心脏缺陷患儿妇女任何心血管疾病住院率的风险比为1.43(95%CI为1.13-1.82),而生出非严重心脏缺陷患儿妇女任何心血管疾病住院率的风险比为1.24(95%CI为1.15-1.34)。生出先天性心脏缺陷婴儿的母亲心血管病住院的具体原因,包括心肌梗死、心力衰竭和其他动脉硬化性疾病的风险也高于生出无心脏缺陷婴儿的母亲。

由此可见,生出先天性心脏缺陷婴儿的妇女在以后的生活中发生心血管住院的风险更大。子代先天性心脏病可能是心血管疾病易感性的早期标志。

原始出处:

Nathalie Auger,et al. Long-Term Risk of Cardiovascular Disease in Women Who Have Had Infants With Heart Defects. Circulation. 2018.https://doi.org/10.1161/CIRCULATIONAHA.117.030277

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    2018-04-02 1de3b290m83(暂无匿称)

    那肯定的.父母为孩子操碎了心

    0

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    2018-04-02 天地飞扬

    学习一下.谢谢分享!

    0

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