Dig Liver Dis:体脂纵向变化对非酒精性脂肪肝发病率和转归的影响

2018-01-30 MedSci MedSci原创

研究结论:内脏脂肪含量增加在纵向上与NAFLD的风险增加有关,与NAFLD的转归成负相关的关系。

研究背景:本研究的目的是调查体脂量变化与非酒精性脂肪性肝病(NAFLD)发病率与转归的纵向联系。

研究方法:从2007年到2008年,开展了一项针对2017例无肝病或大量饮酒史的受试者的队列研究,并参与了2011年至2013年的自愿随访。在这2017例受试者中,956例受试者有2007-2008年和2011-2013年的腹部脂肪数据。NAFLD是在超声检查的基础上被诊断出来的。采用计算机断层扫描法对脂肪组织区域进行评价。

研究结果:在中位随访时间为4.64年间,研究发现145例(22.6%, 642)NAFLD患者,79例(25.2%, 314)NAFLD患者疾病得到缓解。多元分析表明,内脏脂肪组织含量增加与NAFLD高发生率相关(P值取向小于0.001)。内脏脂肪组织含量增加与NAFLD逆转成负相关(P值取向等于0.008)。

研究结论:内脏脂肪含量增加在纵向上与NAFLD的风险增加有关,与NAFLD的转归成负相关的关系。

原始出处

Kim D, Chung GE, Kwak MS, et al. Effect of longitudinal changes of body fat on the incidence and regression of nonalcoholic fatty liver disease.Dig Liver Dis, 2017, Dec 26. pii: S1590-8658(17)31331-2. doi: 10.1016/j.dld.2017.12.014.

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    2018-01-30 137****9095

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    2018-01-30 1e0e5697m83(暂无匿称)

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