Heart:感染性休克患者右心室功能障碍与预后不良之间的关联

2020-07-23 MedSci原创 MedSci原创

三分之一的感染性休克患者表现出各种心肌功能障碍。左室收缩功能不全较为常见的。然而,只有RV功能障碍与短期死亡率有关。

脓毒症引起的心肌功能障碍(SIMD)可以累及左右心室。但是,SIMD各种表现形式的特征和结局尚未明确。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,这是一项回顾性队列研究,研究人员使用了2011年1月至2017年4月期间感染性休克前瞻性登记中心数据。入院后72小时内研究人员将临床上​推测为心脏功能障碍的患者进行了超声心动图检查,并招募入组(n=778)。SIMD分为左心室(LV)收缩/舒张功能障碍和右心室(RV)功能障碍,这是根据美国超声心动图学会标准定义的。该研究的主要结局为28天死亡率。

778名接受超声心动图检查的感染性休克患者中,有270名(34.7%)患者为SIMD。中位年龄为67.0岁,男性为主(57.3%)。其中,LV收缩功能障碍占67.3%,RV收缩功能障碍占40.7%,LV舒张功能障碍占39.3%。尽管两组之间的血清乳酸水平和顺序器官衰竭评估得分没有显著差异,但SIMD组肌钙蛋白I水平较高(0.1 vs. 0.1 ng/mL;p=0.02)和临床结局较差,包括较高的28天死亡率(35.9 vs. 26.8%;p<0.01),重症监护病房住院时间更长(5 vs. 2天; p<0.01)和机械通气时间延长(9 vs. 4天;p<0.01)。多变量分析表明,孤立的RV功能障碍是28天死亡率的独立危险因素(OR为2.26,95%CI为1.04至4.91)。

由此可见,三分之一的感染性休克患者表现出各种心肌功能障碍。左室收缩功能不全较为常见的。然而,只有RV功能障碍与短期死亡率有关。

原始出处:

June-sung Kim.et al.Association between right ventricle dysfunction and poor outcome in patients with septic shock.heart.2020.https://heart.bmj.com/content/early/2020/07/21/heartjnl-2020-316889

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    2020-07-25 zhaojie88
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  5. 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  6. 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  7. 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createdName=老婆子, createdTime=Thu Jul 23 15:04:15 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804093, encodeId=6e4f80409308, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200723/adb4376cbd5d459bb45009c6c6b05ecc/55995743923b4478b36e78dd619b80ef.jpg, createdBy=69fc2504212, createdName=qaz1987623_55203325, createdTime=Thu Jul 23 12:52:45 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-25 slcumt
  8. 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  9. 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    2020-07-23 老婆子

    脓毒症引起心功能障碍

    0

  10. 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    2020-07-23 qaz1987623_55203325

    学习了

    0

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引言 在感染性休克中,最佳的血压和心输出量已经证实并不能充分阻止系统性器官功能衰竭。这衍生了很多对感染性休克的病理生理学的疑惑,使我们的研究偏向于组织灌注的方面。从此以后试验性和临床研究逐渐集中在分析小血管的血流,揭示了微循环异常的复杂状态,提出早期与器官功能衰竭和患者预后直接相关。目前开始关注如何在床旁来评估微循环,如何将这些信息整合来指导治疗,就像是否需要液体的管理或者血管活性药物剂量的