Am J Gastroenterol:一般人群中功能性胃肠病发病率及严重程度

2017-11-26 zhangfan MedSci原创

研究发现,约1/3的成年人群满足功能性胃肠病罗马IV诊断标准,而约1/3的患者存在多个功能性胃肠病指征,严重影响患者的健康以及日常生活质量

近日研究人员以及罗马IV诊断标准,考察了一般人群中功能性胃肠病(FGID)的发病率以及健康损害累积效应。

6300名成人志愿者参与研究,其中5931人完成了调查。调查内容包括人口统计学,药物,手术史,精神及躯体状态,生活质量(QOL),器质性胃肠病并将调查结果与功能性胃肠病罗马IV诊断标准相比较。

研究发现,有FGID症状的人数2083人(35%),无症状人数3421人(57.7%)而器质性胃肠疾病患者427人(7.2%) 。最常见的FGID临床症状表现为肠病(n=1665, 28.1%),其次是胃十二指肠疾病(n=627, 10.6%)、肛门直肠疾病(n=440, 7.4%)、食道疾病(n=414, 7%)以及胆囊疾病(n=10, 0.2%)。FGID症状人群平均满足1.5个FGID指征,其中36%的症状人群有多个症状。多症状人群精神及躯体状态差、生活质量差、需要药物治疗并且腹部手术的风险提高,多症状功能性肠胃病患者的生活质量得分显著低于器质性胃肠疾病患者。

研究发现,约1/3的成年人群满足功能性胃肠病罗马IV诊断标准,而约1/3的患者存在多个功能性胃肠病指征,严重影响患者的健康以及日常生活质量。

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265930, encodeId=bd4626593092, content=学习了提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 01 10:51:56 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-07 许安
  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265930, encodeId=bd4626593092, content=学习了提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 01 10:51:56 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-05 虈亣靌

    讲解的非常好,值得学习

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265930, encodeId=bd4626593092, content=学习了提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 01 10:51:56 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-01 半夏微凉

    学习了谢谢分享

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265930, encodeId=bd4626593092, content=学习了提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 01 10:51:56 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-01 虈亣靌

    学习了提高了

    0

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DDW 2016:罗马Ⅳ颁布功能性胃肠病诊断新标准

在2016 美国消化疾病周(DDW)召开的“罗马基金会和美国消化病学会(AGA)专题报告”会议上,罗马基金会主席、罗马Ⅳ标准总主编德罗斯曼(Douglas DDrossman)教授发布了“功能性胃肠病:罗马Ⅳ”出版的消息,并介绍了罗马Ⅳ标准的更新点;来自澳大利亚的塔利(Nicholas Talley)教授和西班牙的梅亚林(Fermin Mearin)教授分别就功能性消化不良(FD)和肠易激综合

Gut:功能性胃肠病病理生理机制专家共识

功能性胃肠道疾病病理生理学共识将极大推动疾病的临床诊断以及治疗药物的开发

AP&T:β-2肾上腺素能受体多态性可预测功能性胃肠病

β-2肾上腺素能受体(ADRB2),是疼痛信号传导中的神经递质—肾上腺素的重要靶受体。ADRB2单倍型可影响受体表达和配体反应,并与非GI疾病的疼痛有关。来自美国的V. M. Kushnir、B. Cassell、C. P. Gyawali等人近日发表论文,该研究评价对于功能性胃肠病诊断(FGID)及肠外功能性(EIFD)诊断,ADRB2的基因多态

胃肠道黏膜炎症—5-HT系统:或为FGID治疗新靶点

功能性胃肠病(FGID)是指一组具有消化系统症状但缺乏消化道器质性病变或其他证据的疾病,主要包括功能性消化不良(FD)、肠易激综合征(IBS)等。随着人们生活和工作压力越来越大,FGID的患病率明显升高,患者的生活质量、心理状态颇受影响,而医生面对这些患者也常感困惑。FGID的病因和发病机制尚不明确,可能存在多种因素共同作用。在2014胃肠动力和脑肠轴学术研讨会上,上海交通大学医学院附属仁济医院陈

这种功能性胃肠病,吃遍胃药不见效

吴杰介绍,这几年到消化内科求诊的患者有一半左右都是功能性胃肠病,这类患者一般无需吃药,自我调整心理最重要。