Hypertension:饮食钠(即食盐)与血压存在消极性关系,并可受其他膳食因素影响

2018-03-07 MedSci MedSci原创

现有数据表明饮食中的钠(Na,即食盐)与血压(BP)直接相关。但这些发现大多来源于缺乏饮食数据的研究;因此,Na-BP关系是否受其他饮食因素的调控尚不能明确。现研究人员通过控制多重非饮食因素(除了体重指数)发现,对于INTERMAP研究的多个国家的4680位40-59岁的受试者(男女均有),24小时尿钠排泄量和尿钠/钾比值与血压存在直接关系,例如,对于其中的2195位美国受试者,24小时尿钠排泄高

现有数据表明饮食中的钠(Na,即食盐)与血压(BP)直接相关。但这些发现大多来源于缺乏饮食数据的研究;因此,Na-BP关系是否受其他饮食因素的调控尚不能明确。

现研究人员通过控制多重非饮食因素(除了体重指数)发现,对于INTERMAP研究的多个国家的4680位40-59岁的受试者(男女均有),24小时尿钠排泄量和尿钠/钾比值与血压存在直接关系,例如,对于其中的2195位美国受试者,24小时尿钠排泄高于2SD(118.7mmol)与心脏收缩压高3.7mmHg以上相关。将13种大量元素、12种维生素、7种矿物质和18中氨基酸,甚至两性、老年人和年轻人、黑人、西班牙人、白人乃至社会经济阶层等因素纳入控制后,依然可见Na-BP关系。当控制体重指数时,Na-BP(不包括Na/K-BP)关系减弱。正常体重和肥胖受试者的尿钠和BP呈正相关;对于超重人群相关性减弱。24小时钠排泄水平较低(非较高)时,摄入K可削弱Na-BP关系。饮食钠与BP的消极性关系,可受其他饮食成分小程度的影响。

本研究强调了减少盐摄入量对预防和控制高血压前期和高血压的重要意义。

原始出处:

Jeremisah Stamler,et al.Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors.Hypertension. March 05,2018.https://doi.org/10.1161/HYPERTENSIONAHA.117.09928

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    2018-07-28 feather89
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    2018-03-09 zhaojie88
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    2018-03-09 lingqf
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