JCLA:甲型流感病毒通过诱导IL‐37抑制流感病毒复制

2019-06-01 不详 网络

流感病毒是严重影响人类健康的主要病原体之一。该病毒能引起强烈的免疫反应,并引发一系列并发症。白细胞介素37 (IL‐37)是一种新发现的细胞因子,在感染和免疫过程中起着重要的调节作用。迄今为止,关于流感病毒感染与IL‐37之间的相关性的研究很少。 本研究采用酶联免疫吸附试验(ELISA)检测115例甲型流感病毒(IAV)感染患者和102例健康受试者血清IL-37水平。实时定量PCR (RT‐

流感病毒是严重影响人类健康的主要病原体之一。该病毒能引起强烈的免疫反应,并引发一系列并发症。白细胞介素37 (IL37)是一种新发现的细胞因子,在感染免疫过程中起着重要的调节作用。迄今为止,关于流感病毒感染IL37之间的相关性的研究很少。

本研究采用酶联免疫吸附试验(ELISA)检测115例甲型流感病毒(IAV)感染患者和102例健康受试者血清IL-37水平。实时定量PCR (RTqPCR)用于检测IAV患者和健康受试者外周血单核细胞(PBMCs)IL - 37表达的差异。用ELISA法和RT - qPCR法检测了感染IAV H3N2A549细胞和PBMCsIL - 37的表达。用人IL - 37处理H3N2‐感染的A549细胞后,用RTqPCR测定病毒RNA的浓度,并通过血凝试验测定流感病毒的滴度。

研究发现,IAV患者血清IL-37水平和PBMCs均高于健康受试者。IL - 37 mRNA和蛋白在IAV‐感染的A549细胞和PBMCs中表达上调,IL - 37蛋白能够抑制IAV RNA的复制。

原始出处:

Feng Zhou,  ChengLiang Zhu ,Influenza A virus inhibits influenza virus replication by inducing IL37

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