Heart:主动脉瓣置换术的严重主动脉瓣狭窄患者左心室充盈压与生存率

2020-02-18 xing.T MedSci原创

由此可见,接受AVR的AS患者术前左室充盈压升高是常见现象,无论其症状状态如何,均具有重要的预后意义。未来的前瞻性研究应明确充盈压升高的患者是否将从早期手术中受益。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在明确超声心动图检查获得的左心室充盈压是否会影响接受主动脉瓣置换术(AVR)的严重主动脉瓣狭窄(AS)患者的生存率。

研究人员回顾性地分析了1383例连续就诊接受AVR的严重AS患者,他们射血分数正常,且具有充盈压数据。根据当前指南,研究人员使用二尖瓣流入量、二尖瓣环形组织多普勒、估计的右心室收缩压和左心房容积指数确定患者左心室充盈压。研究人员使用Cox比例风险回归来评估各种参数对死亡率的影响。

参与者年龄为75±10岁,女性有552名(40%)。左心室充盈压正常有325人(23%),中等的有463人(33%),升高的有595人(43%)。平均随访时间为7.3±3.7年,在30天、1年和5年时的死亡率分别为1.2%、4.2%和18.9%。与正常充盈压患者相比,充盈压升高的患者年龄更大(78±9 vs. 70±12,p<0.001),女性更多(45% vs. 35%,p=0.002),并且纽约心脏功能分级为III–IV级(35% vs. 24%,p=0.004)、冠心病(55% vs. 42%,p<0.001)和左心室向心性肥大(63% vs. 37%,p<0.001)的可能性更大 。校正其他因素后,左心室充盈压升高仍是AVR成功后死亡率的独立预测因素(调整后的HR为1.45(95%CI为1.16至1.81),p=0.005)。

由此可见,接受AVR的AS患者术前左室充盈压升高是常见现象,无论其症状状态如何,均具有重要的预后意义。未来的前瞻性研究应明确充盈压升高的患者是否将从早期手术中受益。

原始出处:

J Thaden.et al.Left ventricular filling pressure and survival following aortic valve replacement for severe aortic stenosis.heart.2020.http://dx.doi.org/10.1136/heartjnl-2019-315908

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    2020-06-02 yxch48
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createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Jun 02 20:46:00 CST 2020, time=2020-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256750, encodeId=453c1256e5063, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332710, encodeId=7bf11332e100b, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357395, encodeId=c30c135e3950a, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367205, encodeId=4e90136e205ce, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23203, encryptionId=b6222320322, topicName=主动脉瓣置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b24249, createdName=medsci246, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413281, encodeId=87c81413281e6, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415614, encodeId=dc931415614cb, content=<a 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time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576759, encodeId=20c215e6759f4, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1734621, encodeId=bac31e34621c2, content=<a href='/topic/show?id=ffcf2114849' target=_blank style='color:#2F92EE;'>#严重主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21148, encryptionId=ffcf2114849, topicName=严重主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54e533785577, createdName=lq0312, createdTime=Fri Nov 27 04:46:00 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742678, encodeId=34c81e4267892, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357395, encodeId=c30c135e3950a, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367205, encodeId=4e90136e205ce, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23203, encryptionId=b6222320322, topicName=主动脉瓣置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b24249, createdName=medsci246, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413281, encodeId=87c81413281e6, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415614, encodeId=dc931415614cb, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563227, encodeId=ee16156322e5e, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576759, encodeId=20c215e6759f4, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=)]
    2020-02-20 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1734621, encodeId=bac31e34621c2, content=<a href='/topic/show?id=ffcf2114849' target=_blank style='color:#2F92EE;'>#严重主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21148, encryptionId=ffcf2114849, topicName=严重主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54e533785577, createdName=lq0312, createdTime=Fri Nov 27 04:46:00 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742678, encodeId=34c81e4267892, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576759, encodeId=20c215e6759f4, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Thu Feb 20 05:46:00 CST 2020, time=2020-02-20, status=1, ipAttribution=)]
    2020-02-20 slcumt
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主动脉瓣置换的传统手术方式为体外循环辅助下经胸骨正中切口。对于高龄和(或)伴有糖尿病、肾功能不全等疾病的患者,常常由于全身情况不佳而无法接受传统手术。据报道,有高达30%~40%的主动脉瓣病变患者因不能耐受手术退而接受药物治疗,严重影响其生活质量。经导管主动脉瓣置换术(TAVI)为近年出现的新颖手术方式,主要通过大动脉(股动脉、锁骨下动脉、腋动脉)途径实施,因创伤小、术后恢复快受到外科医师和高龄患