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J Periodontol：益生元的使用与口腔健康的关系

2018-04-01 MedSci MedSci原创

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直到近些年，益生元的概念才被引入口腔健康。然后很少有已确定的益生元可发挥有益细菌的作用，并可抑制致病物种的生长。该研究旨在通过将生物膜组合物移向更有利的物种主导的微生物群来验证先前鉴定的潜在的益生元底物对多物种培养物的影响。使用包含14种模型口腔细菌物种的恒化器培养物培养生物膜24小时，随后使用益生元溶液一天3次连续3天处理。进一步研究环境因素，如pH、营养物、氧气浓度和益生元剂量对益生元物质功效

直到近些年，益生元的概念才被引入口腔健康。然后很少有已确定的益生元可发挥有益细菌的作用，并可抑制致病物种的生长。该研究旨在通过将生物膜组合物移向更有利的物种主导的微生物群来验证先前鉴定的潜在的益生元底物对多物种培养物的影响。

使用包含14种模型口腔细菌物种的恒化器培养物培养生物膜24小时，随后使用益生元溶液一天3次连续3天处理。进一步研究环境因素，如pH、营养物、氧气浓度和益生元剂量对益生元物质功效的影响。

结果显示，三种潜在的益生元底物，N-乙酰-D-甘露糖胺、琥珀酸和Met-Pro，可带来> 95％的益处。尽管益生元溶液的pH对益生元效应没有影响，但营养物、氧浓度和益生元治疗的相互作用鉴定出N-乙酰基-D-甘露糖胺可作为最有效的口服益生元使用。研究还显示，效果具有明显的剂量依赖性效应，1.0M和1.5M的N-乙酰-D-甘露糖胺产生97％有益物种的生物膜组合物。

综上所述，该研究结果表明，在口腔健康中引入益生元概念或是治疗和预防口腔疾病和促进口腔健康的有效方法。

原始出处：

Slomka V, Herrero ER, et al., Oral prebiotics and the influence of environmental conditions in vitro. J Periodontol. 2018 Mar 25. doi: 10.1002/JPER.17-0437.

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    2018-10-10 feather89

    #PE#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1727210, encodeId=64191e2721066, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Oct 10 12:18:00 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506394, encodeId=6deb1506394f3, content=<a href='/topic/show?id=5277e2246d9' target=_blank style='color:#2F92EE;'>#益生元#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72246, encryptionId=5277e2246d9, topicName=益生元)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9ce9745957, createdName=mnda, createdTime=Tue Apr 03 08:18:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301839, encodeId=800730183983, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Apr 01 23:30:58 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301778, encodeId=8f59301e788d, content=益生元应用广泛, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/13/0e293a15a201ba87105050681af14e5d.jpg, createdBy=edf62290744, createdName=121e6640m66暂无昵称, createdTime=Sun Apr 01 17:44:20 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-03 mnda

    #益生元#

    0

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    2018-04-01 清风拂面

    谢谢分享学习

    0

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    2018-04-01 121e6640m66暂无昵称

    益生元应用广泛

    0