Int Arch Allergy Immunol:树状细胞HIF1α缺失能够减弱过敏性鼻炎的症状和炎症指标

2020-06-30 AlexYang MedSci原创

过敏性鼻炎时世界上最流行的过敏性疾病。其中炎症被认为参与了过敏性鼻炎的过程。之前的研究表明了缺氧诱导因子(HIF)能够促进过敏性鼻炎的额发展,树状细胞也参与了过敏性鼻炎的过程。

过敏性鼻炎时世界上最流行的过敏性疾病。其中炎症被认为参与了过敏性鼻炎的过程。之前的研究表明了缺氧诱导因子(HIF)能够促进过敏性鼻炎的额发展,树状细胞也参与了过敏性鼻炎的过程。

最近,有研究人员探索了树状细胞中HIF1α缺失对过敏性鼻炎的影响。研究人员通过卵清蛋白(OVA)诱导建立了过敏性鼻炎小鼠模型。lgE,白三烯C4(LTC4),嗜酸细胞阳离子蛋白(ECP),前列腺素D2(PGD2),IFN- IL-2, IL-4, IL-5, IL-10和IL-13在血清和鼻灌洗液(NLF)中的水平通过ELISA检测。研究发现,HIF1α在树状细胞中的缺失(HIF1αCD11c-/-)能够减少打喷嚏和挠鼻,血清和NLF中OVA特异性lgE,LTC4和ECP的产生;NLF中白细胞、嗜酸性粒细胞、淋巴细胞和中性粒细胞的数量也均减少。Th1细胞因子增加,Th2细胞因子在HIF1αCD11c-/-小鼠中减少。SIRT1/NF-κB信号在HIF1αCD11c-/-小鼠中受抑制,而SIRT1抑制剂处理HIF1αCD11c-/-小鼠能够减弱过敏性鼻炎的症状和炎症指标。

最后,研究人员指出,HIF1α在树状细胞中的缺失能够以SIRT1依赖的方式减少过敏性鼻炎症状和炎症指标。

原始出处:

Yanliu Niu , Jianquan Wang , Zhen Li et al. HIF1α Deficiency in Dendritic Cells Attenuates Symptoms and Inflammatory Indicators of Allergic Rhinitis in a SIRT1-Dependent Manner. Int Arch Allergy Immunol. 15 June 2020.

 

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    2020-07-02 膀胱癌
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    2020-07-02 wrj0126

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