Ultrasonics:低强度脉冲超声可有效促进牙槽骨再生

2018-08-04 MedSci MedSci原创

牙周炎是一种常见的口腔疾病,其特征在于牙周支持组织的进行性破坏和牙齿丧失。然而,牙周组织的再生是一个漫长的过程。低强度脉冲超声(LIPUS)是一种广泛使用的非侵入性干预手段,用于增强骨折和非愈合中的骨愈合。假设LIPUS可能加速牙周再生,研究人员在体外和体内研究了LIPUS对牙周组织再生的影响。 使用LIPUS(90mw/cm2,20min/d,1.5MHz)刺激狗牙周韧带细胞(dPDLCS)。结

牙周炎是一种常见的口腔疾病,其特征在于牙周支持组织的进行性破坏和牙齿丧失。然而,牙周组织的再生是一个漫长的过程。低强度脉冲超声(LIPUS)是一种广泛使用的非侵入性干预手段,用于增强骨折和非愈合中的骨愈合。假设LIPUS可能加速牙周再生,研究人员在体外和体内研究了LIPUS对牙周组织再生的影响。

使用LIPUS(90mw/cm2,20min/d,1.5MHz)刺激狗牙周韧带细胞(dPDLCS)。结果显示,LIPUS组BSP(P <0.05),OPN(P <0.05)和COL3(P <0.05)mRNA的表达明显增加。LIPUS组茜素红阳性染色矿化结节大于对照组(P <0.05)。

将8只雄性比格犬分成4组:引导组织再生(GTR)组(G1),LIPUS + GTR组(G2),LIPUS组(G3)和对照组(G4,未治疗)。在颊侧牙槽骨中产生4×5mm2的缺损。然后将G2和G3组中的建模区域暴露于LIPUS。

结果显示,手术后8周,IBD%E8%AF%8A%E6%B2%BB%E8%BF%87%E7%A8%8B%E4%B8%AD%E7%9A%84%E8%AF%84%E4%BC%B0-Part%" target="_blank">组织学评估显示LIPUS + GTR组牙周支持组织增加。微型计算机断层扫描(micro-CT)显示G2中的再生骨体积(BV)明显高于G1,G3和G4组(P <0.05)。 G2期骨表面(BS)小梁数(Tb.N)和小梁厚度(Tb.Th)明显高于G4(P <0.05)。

综上所述,该研究结果表明,LIPUS + GTR可以加速新的牙槽骨形成,可促进牙周组织修复再生。

原始出处:

Wang Y, Qiu Y, et al., Low-intensity pulsed ultrasound promotes alveolar bone regeneration in a periodontal injury model. Ultrasonics. 2018 Nov;90:166-172. doi: 10.1016/j.ultras.2018.06.015. Epub 2018 Jun 26.

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    2018-08-14 bsmagic9140
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    2018-10-30 mei540
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    2019-06-01 huangdf
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    2018-08-31 siiner
  6. [GetPortalCommentsPageByObjectIdResponse(id=1657048, encodeId=25bd165e0485e, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Aug 14 17:28:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667898, encodeId=bcb7166e89877, content=<a href='/topic/show?id=64596e594d8' target=_blank style='color:#2F92EE;'>#牙槽骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67594, encryptionId=64596e594d8, topicName=牙槽骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=87b426195956, createdName=mei540, createdTime=Tue Oct 30 06:28:00 CST 2018, time=2018-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1913760, encodeId=57381913e60c7, content=<a href='/topic/show?id=6f5328e398' target=_blank style='color:#2F92EE;'>#ASO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2873, encryptionId=6f5328e398, topicName=ASO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Sat Jun 01 19:28:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957825, encodeId=797f195e825d7, content=<a href='/topic/show?id=aaf96e596e0' target=_blank style='color:#2F92EE;'>#牙槽骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67596, encryptionId=aaf96e596e0, topicName=牙槽骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=09a12500213, createdName=12498f1em08(暂无昵称), createdTime=Mon Jul 01 03:28:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796560, encodeId=a3561e96560c3, content=<a href='/topic/show?id=57211812121' target=_blank style='color:#2F92EE;'>#Ultra#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18121, encryptionId=57211812121, topicName=Ultra)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Fri Aug 31 07:28:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472141, encodeId=1c3814e214103, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Mon Aug 06 05:28:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336368, encodeId=6e2033636822, content=学习了!谢谢作者的分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151002/IMG560DED22850969184.jpg, createdBy=6c9b1653645, createdName=王小白0816, createdTime=Sat Aug 04 14:48:03 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-06 lsj630
  7. [GetPortalCommentsPageByObjectIdResponse(id=1657048, encodeId=25bd165e0485e, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Aug 14 17:28:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667898, encodeId=bcb7166e89877, content=<a href='/topic/show?id=64596e594d8' target=_blank style='color:#2F92EE;'>#牙槽骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67594, encryptionId=64596e594d8, topicName=牙槽骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=87b426195956, createdName=mei540, createdTime=Tue Oct 30 06:28:00 CST 2018, time=2018-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1913760, encodeId=57381913e60c7, content=<a href='/topic/show?id=6f5328e398' target=_blank style='color:#2F92EE;'>#ASO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2873, encryptionId=6f5328e398, topicName=ASO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Sat Jun 01 19:28:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957825, encodeId=797f195e825d7, content=<a href='/topic/show?id=aaf96e596e0' target=_blank style='color:#2F92EE;'>#牙槽骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67596, encryptionId=aaf96e596e0, topicName=牙槽骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=09a12500213, createdName=12498f1em08(暂无昵称), createdTime=Mon Jul 01 03:28:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796560, encodeId=a3561e96560c3, content=<a href='/topic/show?id=57211812121' target=_blank style='color:#2F92EE;'>#Ultra#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18121, encryptionId=57211812121, topicName=Ultra)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Fri Aug 31 07:28:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472141, encodeId=1c3814e214103, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Mon Aug 06 05:28:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336368, encodeId=6e2033636822, content=学习了!谢谢作者的分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151002/IMG560DED22850969184.jpg, createdBy=6c9b1653645, createdName=王小白0816, createdTime=Sat Aug 04 14:48:03 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-04 王小白0816

    学习了!谢谢作者的分享!

    0