Lancet子刊:肺炎球菌可把这个动脉瘤玩大了——案例报道

2016-11-13 MedSci MedSci原创

77岁女性,发热、意识状态改变、颈部僵硬。她是个烟鬼,有高血压和血脂异常,3天前有右侧背部疼痛。 头部CT和胸片均正常,腰椎穿刺和血培养显示肺炎球菌性脑膜炎和菌血症。 开始头孢曲松治疗(2 g,每日2次),患者病情迅速好转,发热解决了,炎症标志物也大量减少了(白细胞计数从19·7/ml下降到14·9/ml,C反应蛋白由225 mg/L下降到108 mg/L)。 然而,病人入院后1

77岁女性,发热、意识状态改变、颈部僵硬。她是个烟鬼,有高血压和血脂异常,3天前有右侧背部疼痛。

头部CT和胸片均正常,腰椎穿刺和血培养显示肺炎球菌性脑膜炎和菌血症。

开始头孢曲松治疗(2 g,每日2次),患者病情迅速好转,发热解决了,炎症标志物也大量减少了(白细胞计数从19·7/ml下降到14·9/ml,C反应蛋白由225 mg/L下降到108 mg/L)。

然而,病人入院后12天,临床和生化改善不到一周,她的背痛情况出现恶化,炎症标志物反弹(白细胞计数19·8/ml,C-反应蛋白为171 mg/L)。

腰椎CT没有发现感染,但有腹主动脉增大,有动脉瘤周围炎症的迹象。CT血管造影检查证实了腹主动脉瘤的存在,并有即将破裂的迹象。



真菌性动脉瘤和微生物血管炎是罕见的,通常发生在有潜在动脉粥样硬化血管疾病的患者中,是菌血症播种异常主动脉表面的后果。临床表现往往是亚急性的,诊断往往延迟或作不出诊断,直到死亡后。尽管肺炎链球菌是菌血症的常见原因,却很少引起血管播种。肺炎球菌主动脉炎应排除有典型腹主动脉瘤症状、高危心血管疾病的脓毒症患者。

病人及时进行了同种主动脉-主动脉瓣置换术。术后患者恢复可,没有任何并发症。然而,1个月后的CT血管造影显示,疾病似乎又开始进展了。



但病人拒绝任何手术。从那时起,对患者进行严格的临床和放射学随访检查,不够没有发现并且进一步恶化的证据。经过近12个月,她仍然活着,临床情况也较好。

原始出处:

Davide Mangioni,et al.Abdominal aortitis and aneurysm impending rupture during pneumococcal meningitis.The Lancet Infectious Diseases.Volume 16, No. 8, p980, August 2016

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    2017-10-13 howi
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    2016-11-15 1dd8c52fm63(暂无匿称)

    了解了解!

    0

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    2016-11-14 李东泽

    很好,不错,以后会多学习

    0

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    2016-11-14 刘煜

    学习新知识谢谢分享。

    0

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    2016-11-14 老段

    学习了,赞一个!

    0

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    2016-11-13 上邪zyy

    看看,学习一下

    0

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