JAMA Intern Med:强化降压可降低慢性肾病患者死亡风险

2017-09-12 zhangfan MedSci原创

强化动脉压控制可显著降低高血压并慢性肾病患者的全因死亡风险

强化降压试验可降低心血管疾病患者的全因死亡风险,但慢性肾病(CKD)的发病率和进展影响尚不清楚。近日研究人员对强化收缩压降低与CKD的关系进行了系统研究。

研究人员对相关随机临床试验结果进行系统回顾和荟萃分析,以考察强化血压控制与CKD 3-5阶段患者死亡率之间的关系。

研究共包含了30个临床研究,从18个子集中提取CDK死亡数据,共15924名参与者,其中1293人死亡,患者基线平均动脉压为148mmHg。在强化血压控制组,患者动脉压平均下降16mmHg至132mmHg,血压控制组患者平均动脉压下降8mmHg至140mmHg,强化血压控制可降低14%的全因死亡率(OR 0.86;95% CI,0.76-0.97),该结果无显著异质性且在多个亚群中保持一致。

研究发现,强化动脉压控制可显著降低高血压并慢性肾病患者的全因死亡风险。

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    2017-09-14 大爰

    学习了谢谢分享!!

    0

  5. 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  8. 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  9. 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    2017-09-12 184****9840

    学习了受益匪浅

    0

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    2017-09-12 Y—xianghai

    学习了新知识

    0

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2016共识声明:患有糖尿病和慢性肾病患者应用抗糖尿病药物的剂量调整

糖尿病患者肾功能衰退对于临床医生来讲具有挑战性,包括并发症的管理例如,高血压高脂血症,心血管疾病,贫血等。本文主要针对糖尿病和慢性肾病患者应用抗糖尿病药物的剂量调整提出指导建议。

Circulation:慢性肾病与心脏疾病密切相关,增加了心血管疾病患者的不良预后风险!

慢性肾病(CKD)被认为是全球公共卫生问题。最新的国际临床指南强调肾小球滤过率(GFR)和蛋白尿。CKD与心脏疾病密切相关,增加心血管疾病(CVD)患者的不良预后风险。事实上,大量的研究已经研究了CKD预后与心血管病患者的关系,但大多数研究都集中在肾功能上,对蛋白尿研究的数据有限。

Nephrology :慢性肾病:甲状旁腺激素治疗的目标及对甲状旁腺功能亢进症的管理

矿物质骨疾病常见于慢性肾病中,主要受继发性甲状旁腺功能亢进症(HPT)驱动。其诊断和治疗是复杂的,但对甲状旁腺激素(PTH)的测量和制定目标是几十年来治疗的重点。2017年5月,发表在《Nephrology (Carlton)》的一项由澳大利亚科学家进行的研究,考察了慢性肾病(CKD)患者进行甲状旁腺激素(PTH)治疗的目标及对HPT的管理。