Nature:自然杀伤细胞与潜伏性结核有关

2018-08-23 唐一尘 中国科学报

《自然》8月23日在线发表的一篇论文称,较高水平的自然杀伤细胞与潜伏性结核相关。这一发现令人产生一个疑问,即自然杀伤细胞是否可能在结核感染中发挥重要作用。

《自然》8月23日在线发表的一篇论文称,较高水平的自然杀伤细胞与潜伏性结核相关。这一发现令人产生一个疑问,即自然杀伤细胞是否可能在结核感染中发挥重要作用。

结核病是一种细菌性疾病,也是导致相关死亡的主要原因。大部分结核感染都是潜伏性的,即无外在症状,而处于一种不会蔓延的状态。据估计,全球有1/4的人口感染潜伏性结核,但是不到10%的潜伏性结核病例最终会进展为活动性结核感染。尽管如此,人们对于会影响个体感染结果的免疫因素仍知之甚少。

为了理解引起潜伏的免疫状态以及该状态是否会在疾病进展后发生改变,美国斯坦福大学的Yueh-hsiu Chien、斯坦福大学医学院的Purvesh Khatri及同事开展了多项队列研究,将大量细胞计数法与基因表达数据集相结合,借此鉴定未感染被试与潜伏性或活动性结核被试之间的免疫细胞群差异。

他们发现潜伏性结核与较多的自然杀伤细胞(能够杀死特定病原体的白血球)相关,与未感染的被试相比,潜伏性结核被试的抗毒素反应更强。而在活动性结核被试体内,自然杀伤细胞数量较少,但是在感染治愈后,其数量会恢复至基准水平。尽管如此,以上发现无法证明自然杀伤细胞与潜伏性结核存在因果关系。

此外,研究人员表明测量自然杀伤细胞水平可用于判断病人肺结核感染的活动水平和感染负担,该发现或有助于评估疾病进展,优化治疗方案。

原始出处:

Roshni Roy Chowdhury, Francesco Vallania, Qiantian Yang, et.al. A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes. Nature 22 August 2018

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    2019-01-18 liye789132251
  2. [GetPortalCommentsPageByObjectIdResponse(id=1883264, encodeId=086c18832649c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jan 18 23:03:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348395, encodeId=8fda34839534, content=之前在医生站看过篇用血液诊断结核活动的文章,找不到了。结核性胸膜炎怎么快速诊断?, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=06f52209211, createdName=120d0139m64暂无昵称, createdTime=Sun Oct 07 20:09:11 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341158, encodeId=f07c34115853, content=哈哈哈,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1ee1608797, createdName=huangshang9812, createdTime=Mon Aug 27 14:24:12 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1254203, encodeId=8ba6125420338, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Aug 25 05:03:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487934, encodeId=9e52148e934dc, content=<a href='/topic/show?id=72a98625851' target=_blank style='color:#2F92EE;'>#自然杀伤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86258, encryptionId=72a98625851, topicName=自然杀伤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=43638387861, createdName=habb, createdTime=Sat Aug 25 05:03:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340470, encodeId=26143404e0e6, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Aug 24 07:10:51 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340381, encodeId=fbad3403811e, content=可以指导临床判断活动, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f1e2426306, createdName=123a8481m90暂无昵称, createdTime=Thu Aug 23 15:57:31 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340380, encodeId=f02a34038086, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f1e2426306, createdName=123a8481m90暂无昵称, createdTime=Thu Aug 23 15:55:52 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340367, encodeId=210934036e0d, content=自然杀伤细胞与结核。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Thu Aug 23 14:18:24 CST 2018, time=2018-08-23, status=1, ipAttribution=)]
    2018-10-07 120d0139m64暂无昵称

    之前在医生站看过篇用血液诊断结核活动的文章,找不到了。结核性胸膜炎怎么快速诊断?

    0

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    2018-08-27 huangshang9812

    哈哈哈,学习了

    0

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    2018-08-24 kafei

    了解一下谢谢

    0

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    2018-08-23 123a8481m90暂无昵称

    可以指导临床判断活动

    0

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    2018-08-23 123a8481m90暂无昵称

    学习了

    0

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    2018-08-23 liumin1987

    自然杀伤细胞与结核。

    0

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