J Tissue Eng:低强度高频振动对聚乙二醇微囊化间充质干细胞的影响

2018-09-24 MedSci MedSci原创

当细胞在某些类型的三维环境中培养时,低强度的高频振动可刺激间充质干细胞的成骨。 然而,既往研究关于成骨的结果存在一些矛盾,这些研究并没有探究振动的影响。 本研究中,研究人员使用天然来源的支架探究振动对间充质干细胞成骨的影响。由于这些天然来源可能具有固有的生化和微结构线索,我们探讨了当间充质干细胞被包裹在聚(乙二醇)二丙烯酸酯微球中时,低、中和高加速度下的低幅度、高频振动对间充质干细胞的成骨

当细胞在某些类型的三维环境中培养时,低强度的高频振动可刺激间充质干细胞的成骨。 然而,既往研究关于成骨的结果存在一些矛盾,这些研究并没有探究振动的影响。

本研究中,研究人员使用天然来源的支架探究振动对间充质干细胞成骨的影响。由于这些天然来源可能具有固有的生化和微结构线索,我们探讨了当间充质干细胞被包裹在聚(乙二醇)二丙烯酸酯微球中时,低、中和高加速度下的低幅度、高频振动对间充质干细胞的成骨影响。

结果显示,低和中等加速度可增强间充质干细胞的成骨,而高加速度则会抑制间充质干细胞的成骨。

综上所述,该研究结果表明单独振动的孤立效应也可诱导间充质干细胞成骨。

原始出处:

Sneha Mehta, Brooke McClarren, et al., The effect of low-magnitude, high-frequency vibration on poly(ethylene glycol)-microencapsulated mesenchymal stem cells. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418800101.

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    2019-05-02 xuyu
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    2018-11-16 weiz
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    2018-09-30 spoonycyy
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    2018-09-24 医者仁心5538

    学习了

    0