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JCEM：细胞因子与糖尿病进展之间的关联

2019-11-09 xing.T MedSci原创

细胞因子糖尿病关联
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由此可见，在这项为期10年的前瞻性研究中，NGT的血清RBP4和PAI-1较高，并且脂联素含量较低与新发糖尿病和2型糖尿病有关。

目前尚不确定多种细胞因子与糖尿病进展之间的长期关联情况。近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员旨在确定在10年内哪些细胞因子可以预测糖尿病前期和2型糖尿病的进展。

该研究纳入了来自Ansung队列的912名年龄在40至69岁的参与者，是韩国基因组流行病学研究的一部分。在基线时，受试者进行了75 g口服葡萄糖耐量试验和八种细胞因子的测定：纤溶酶原激活物抑制剂1（PAI-1）、抵抗素、白介素6、瘦素、单核细胞趋化因子1、肿瘤坏死因子 -α、视黄醇结合蛋白4（RBP4）和脂联素。糖耐量正常（NGT，n=241）和糖尿病前期（n=330）的受试者每两年进行一次随访，为期10年。研究人员使用多重Logistic回归分析来评估新发糖尿病和2型糖尿病患者细胞因子的预测价值。

在10年时，分别有38（15.8％）和82（34.0％）名NGT受试者已转变为糖尿病前期和2型糖尿病患者。在糖尿病前期患者中，有228人（69.1％）已转变为2型糖尿病。在基线时NGT或糖尿病前期受试者中，RBP4的最高三分位数分别与2型糖尿病的风险增加5.48倍和2.43倍相关。PAI-1最高三分位数和脂联素最低三分位数的受试者从NGT转换为糖尿病前期的几率分别为3.23和3.37。在基线糖尿病前期患者中，抵抗素最高三分位数的人群罹患2型糖尿病的可能性增加2.94倍（所有p<0.05）。

由此可见，在这项为期10年的前瞻性研究中，NGT的血清RBP4和PAI-1较高，并且脂联素含量较低与新发糖尿病和2型糖尿病有关。 

原始出处：

Nam Han Cho,et al.Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-up from a Community-based Cohort.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz171

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    2020-08-15 achengzhao

    #JCE#

    0

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    2020-09-22 smallant2015

    #JCEM#

    0

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    2019-12-29 ms7019579240139182

    #胞因子#

    0

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    2019-11-11 axin009

    #细胞因子#

    0

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    2019-11-09 misszhang

    谢谢MedSci提供最新的资讯

    0

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