NEJM:肺癌治疗后的杵状指转归-案例报道

2016-09-23 MedSci MedSci原创

患者女性,59岁,既往有吸烟史60余年,近日因出现进行性呼吸困难和杵状指超过1年余而到院就诊(如图A)。  计算机断层扫描显示,左下叶的肺部可见一肿块(如图B)。  经支气管镜取样活检显示非小细胞癌和未分化–免疫组化染色阳性的肿瘤蛋白63和细胞角蛋白5/6抗体,这一结果与低分化鳞状细胞肺癌的诊断标准一致。  最后,该患者接受卡铂和紫杉醇药物进行化疗和放疗,同时,

患者女性,59岁,既往有吸烟史60余年,近日因出现进行性呼吸困难和杵状指超过1年余而到院就诊(如图A)。

 
计算机断层扫描显示,左下叶的肺部可见一肿块(如图B)。

经支气管镜取样活检显示非小细胞癌和未分化–免疫组化染色阳性的肿瘤蛋白63和细胞角蛋白5/6抗体,这一结果与低分化鳞状细胞肺癌的诊断标准一致。

最后,该患者接受卡铂和紫杉醇药物进行化疗和放疗,同时,其参与了一个程序性死亡配体免疫治疗试验(PD-L1)辅助治疗。

经治疗6个月后,患者杵状指的症状开始明显地有所改善(如图C),呼吸困难症状也有所好转。

再次行计算断层扫描检查,结果显示肿块的大小明显减小(如图D)。

通常,在临床上,对于肺癌的诊断,患者杵状指指甲的表现对于肺部疾病的确诊非常有利。 

原始出处: 

Ari J. Ciment, M.D., and Larry Ciment, M.D. Regression of Clubbing after Treatment of Lung CancerN Engl J Med 2016; 375:1171September 22, 2016 

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1734853, encodeId=a2d91e3485393, content=<a href='/topic/show?id=eb82822328e' target=_blank style='color:#2F92EE;'>#肺癌治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82232, encryptionId=eb82822328e, topicName=肺癌治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=267533842346, createdName=马龙, createdTime=Tue Oct 25 13:51:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152018, encodeId=85c815201899, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Oct 29 16:17:41 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148315, encodeId=4743148315b5, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Oct 14 23:14:09 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623556, encodeId=5861162355657, content=<a href='/topic/show?id=b41b61639a7' target=_blank style='color:#2F92EE;'>#杵状指#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61639, encryptionId=b41b61639a7, topicName=杵状指)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9d20545227, createdName=july_982, createdTime=Sun Sep 25 02:51:00 CST 2016, time=2016-09-25, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1734853, encodeId=a2d91e3485393, content=<a href='/topic/show?id=eb82822328e' target=_blank style='color:#2F92EE;'>#肺癌治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82232, encryptionId=eb82822328e, topicName=肺癌治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=267533842346, createdName=马龙, createdTime=Tue Oct 25 13:51:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152018, encodeId=85c815201899, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Oct 29 16:17:41 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148315, encodeId=4743148315b5, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Oct 14 23:14:09 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623556, encodeId=5861162355657, content=<a href='/topic/show?id=b41b61639a7' target=_blank style='color:#2F92EE;'>#杵状指#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61639, encryptionId=b41b61639a7, topicName=杵状指)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9d20545227, createdName=july_982, createdTime=Sun Sep 25 02:51:00 CST 2016, time=2016-09-25, status=1, ipAttribution=)]
    2016-10-29 李东泽

    这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1734853, encodeId=a2d91e3485393, content=<a href='/topic/show?id=eb82822328e' target=_blank style='color:#2F92EE;'>#肺癌治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82232, encryptionId=eb82822328e, topicName=肺癌治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=267533842346, createdName=马龙, createdTime=Tue Oct 25 13:51:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152018, encodeId=85c815201899, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Oct 29 16:17:41 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148315, encodeId=4743148315b5, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Oct 14 23:14:09 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623556, encodeId=5861162355657, content=<a href='/topic/show?id=b41b61639a7' target=_blank style='color:#2F92EE;'>#杵状指#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61639, encryptionId=b41b61639a7, topicName=杵状指)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9d20545227, createdName=july_982, createdTime=Sun Sep 25 02:51:00 CST 2016, time=2016-09-25, status=1, ipAttribution=)]
    2016-10-14 李东泽

    很好,不错,以后会多学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1734853, encodeId=a2d91e3485393, content=<a href='/topic/show?id=eb82822328e' target=_blank style='color:#2F92EE;'>#肺癌治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82232, encryptionId=eb82822328e, topicName=肺癌治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=267533842346, createdName=马龙, createdTime=Tue Oct 25 13:51:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152018, encodeId=85c815201899, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Oct 29 16:17:41 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148315, encodeId=4743148315b5, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Oct 14 23:14:09 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623556, encodeId=5861162355657, content=<a href='/topic/show?id=b41b61639a7' target=_blank style='color:#2F92EE;'>#杵状指#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61639, encryptionId=b41b61639a7, topicName=杵状指)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9d20545227, createdName=july_982, createdTime=Sun Sep 25 02:51:00 CST 2016, time=2016-09-25, status=1, ipAttribution=)]
    2016-09-25 july_982

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