Diabetes:HIIT能否减少1型糖尿病患者低血糖后认知障碍的发生?

2017-07-25 顾歆纯 环球医学资讯

2017年7月,发表在《Diabetes》的一项由荷兰和英国科学家进行的研究表明,高强度间歇训练(HIIT)降低1型糖尿病患者对后续低血糖的认知。

2017年7月,发表在《Diabetes》的一项由荷兰和英国科学家进行的研究表明,高强度间歇训练(HIIT)降低1型糖尿病患者对后续低血糖的认知。

HIIT在糖尿病患者中的流行程度越来越高。HIIT可急性增加血浆乳酸水平,这是非常重要的,这是由于低血糖期间乳酸给药会在保留认知功能的同时抑制症状和反调节。研究者检验了假设,即短期时间内,HIIT可降低低血糖的认知,减弱低血糖诱导的认知功能障碍。

在一项随机交叉试验中,正确认知低血糖(NAH)的1型糖尿病患者、低血糖认知受损(IAH)患者和健康参与者(每组10人)在HIIT课程后或坐着休息后进行了高胰岛素低血糖钳(2.6mmol/L)。与休息相比,HIIT减弱了NAH患者低血糖的症状,而健康参与者或IAH患者未发生此现象。HIIT可减弱低血糖诱导的认知功能障碍,这主要由NAH亚组的改变而造成。HIIT可抑制皮质醇和生长激素应答,但是不会抑制对低血糖的儿茶酚胺应答。

现有结果证实,单一的HIIT课程可快速降低1型糖尿病和NAH而非IAH患者随后低血糖的认知,减弱低血糖诱导的认知功能障碍。锻炼诱导的乳酸在调节这些影响中的作用,尤其是作为大脑的替代刺激物,需要进一步讨论。

(专家点评:糖尿病患者的运动是糖尿病疾病控制五驾马车之一,但也往往是最容易被忽略的一点。运动能够降低患者体重,增加胰岛素敏感性。本研究发现HIIT运动能够减少1型糖尿病患者低血糖后认知障碍的发生,临床上应建议有条件的患者进行HIIT运动,特别是易发生低血糖的患者。)

原始出处:
Rooijackers HM, Wiegers EC, van der Graaf M, et al.A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes.Diabetes. 2017 Jul;66(7):1990-1998. doi: 10.2337/db16-1535. Epub 2017 Apr 18.

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