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Arthritis Rheumatol：关节内注射CNTX-4975（反式辣椒素）治疗膝骨性关节炎相关疼痛

2019-04-04 xiangting MedSci原创

膝骨性关节炎CNTX-4975疼痛辣椒素
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这项研究中，CNTX-4975使得膝关节OA相关疼痛得到剂量依赖性改善。

TRIUMPH研究评估了高纯度合成反式辣椒素（CNTX-4975）在慢性骨关节炎相关中至重度膝关节疼痛患者中的疗效和安全性。

在这项双盲、多中心、2期研究中，年龄45-80岁的稳定膝骨性关节炎受试者以2：1：2的比例随机接受单次关节内注射安慰剂、CNTX-4975 0.5mg，或CNTX-4975 1.0mg。主要疗效终点是12周内每日西安大略省和麦克马斯特大学骨关节炎指数（WOMAC）问题A1（QA1）行走疼痛评分（0 [无]至10 [极度]）从基线变化的曲线下面积（AUC）。次要疗效终点包括对CNTX-4975 0.5mg治疗受试者的结局进行类似的AUC分析，和将评估延长至24周。

在172名受试者中评估疗效（安慰剂，n=69；CNTX-4975 0.5mg，n=33；CNTX-4975 1.0mg，n=70）。在第12周，与安慰剂相比，CNTX-4975 0.5和1.0mg组AUC疼痛降低的更多（0.5mg：LSMD，-0.79；P=0.0740；1.0mg：LSMD，-1.6；P<0.0001）。1.0mg组的显著改善维持至第24周（LSMD，-1.4；P=0.0002）。安慰剂组和1.0mg组的治疗相关不良事件相似。

这项研究中，CNTX-4975使得膝关节OA相关疼痛得到剂量依赖性改善。CNTX-4975 1.0 mg显著减轻骨关节炎引起的膝关节疼痛，直至24周；CNTX-4975 0.5 mg在12周时显著改善疼痛，但到24周时疗效不明显。

原始出处：

Randall M. Stevens. Randomized, Double‐Blind, Placebo‐Controlled Trial of Intra‐articular CNTX‐4975 (trans‐capsaicin) for Pain Associated With Osteoarthritis of the Knee. Arthritis Rheumatol. March 2019.

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    2022-06-18 屋顶瞄爱赏月

    学习

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    2022-02-18 屋顶瞄爱赏月

    学习了

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topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357154, encodeId=6114135e15496, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=)]
    2020-11-14 lovetcm

    反式辣椒素，进一步针对#辣椒素#进行开发，未来可能成为抗#癌症#，#心血管#疾病，#骨关节炎#等良药！因为#辣椒#性热，对一切进寒湿相关的疾病可能均有治疗作用。

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899175, encodeId=83bc8991e595, content=反式辣椒素，进一步针对<a href='/topic/show?id=48fc938643d' target=_blank style='color:#2F92EE;'>#辣椒素#</a>进行开发，未来可能成为抗<a href='/topic/show?id=d8dbe130197' target=_blank style='color:#2F92EE;'>#癌症#</a>，<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>疾病，<a href='/topic/show?id=6d7510159e72' target=_blank style='color:#2F92EE;'>#骨关节炎#</a>等良药！因为<a href='/topic/show?id=85b6938639d' target=_blank style='color:#2F92EE;'>#辣椒#</a>性热，对一切进寒湿相关的疾病可能均有治疗作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=236, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93864, encryptionId=48fc938643d, topicName=辣椒素), TopicDto(id=71301, encryptionId=d8dbe130197, topicName=癌症), TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管), TopicDto(id=101597, encryptionId=6d7510159e72, topicName=骨关节炎), TopicDto(id=93863, encryptionId=85b6938639d, topicName=辣椒)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Nov 14 17:16:17 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972631, encodeId=93a019e263105, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Nov 30 17:57:00 CST 2019, 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topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357154, encodeId=6114135e15496, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=)]
    2019-11-30 ms6390871039024434

    #Arthritis#

    0

  5. 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    2019-10-25 wjywjy

    #CNTX-4975#

    0

  6. 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topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357154, encodeId=6114135e15496, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=)]
    2019-10-27 zhangpaul93

    #膝骨#

    0

  7. 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encryptionId=85b6938639d, topicName=辣椒)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Nov 14 17:16:17 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972631, encodeId=93a019e263105, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Nov 30 17:57:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783275, encodeId=389b1e832755f, content=<a href='/topic/show?id=bbe54944b3' target=_blank style='color:#2F92EE;'>#CNTX-4975#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4944, encryptionId=bbe54944b3, topicName=CNTX-4975)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Fri Oct 25 10:57:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1747037, encodeId=773d1e470370a, content=<a href='/topic/show?id=495385896b5' target=_blank style='color:#2F92EE;'>#膝骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85896, encryptionId=495385896b5, topicName=膝骨)], attachment=null, 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topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357154, encodeId=6114135e15496, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=)]
    2019-10-10 lmm397

    #膝骨性关节炎#

    0

  8. 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topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357154, encodeId=6114135e15496, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 06 01:57:00 CST 2019, time=2019-04-06, status=1, ipAttribution=)]
    2019-04-06 智智灵药

    #关节炎#

    0

  9. 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    2019-04-06 zhaojie88

    #ART#

    0

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