Br J Cancer：靶向治疗后达到完全缓解的黑色素瘤患者，能停药吗？

2016-10-20 MedSci MedSci原创

靶向治疗下，达到完全缓解的黑色素瘤患者，能否安全地停止治疗？为了探究这个问题，我们对所有使用BRAF / MEK抑制剂治疗、达到完全缓解、在疾病进展前完全停药的黑色素瘤患者进行了研究分析。检查了患者开始治疗、停药和疾病进展时的相关临床数据。本研究共对12名符合条件的患者进行了鉴定，中位数随访16个月，其中6例（50%）复发，治疗结束后到复发的中位数时间为6.6个月。一例患者

靶向治疗下，达到完全缓解的黑色素瘤患者，能否安全地停止治疗？

为了探究这个问题，我们对所有使用BRAF / MEK抑制剂治疗、达到完全缓解、在疾病进展前完全停药的黑色素瘤患者进行了研究分析。检查了患者开始治疗、停药和疾病进展时的相关临床数据。

本研究共对12名符合条件的患者进行了鉴定，中位数随访16个月，其中6例（50%）复发，治疗结束后到复发的中位数时间为6.6个月。

一例患者出现症状性复发后失去随访，是唯一一例复发到死亡的案例。

剩下的5例复发患者，LDH <1.2倍ULN，4例患者 ECOG 0，还要1例患者ECOG 1。基线特征、完全缓解时间、停药时间等对复发率没有影响。

使用BRAF / MEK抑制剂治疗、达到完全缓解后停药的患者中，较大比例患者出现复发。这类患者的最佳治疗时间仍不清楚。

原始出处：

Carlino MS.et al.Cessation of targeted therapy after a complete response in BRAF-mutant advanced melanoma: a case series.Br J Cancer. 2016 Oct 6. doi: 10.1038/bjc.2016.321. [Epub ahead of print]

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#插入话题

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2017-07-03 小小小向日葵

#完全缓解#

36 0
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2017-01-04 sunylz

#色素#

41 0
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2016-11-11 虈亣靌

讲的好，学习了

75 0
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2016-10-25 cqykthl

恶性程度高

79 0
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2016-10-23 长乐江田皮肤科门诊部

不能停药。

77 0
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2016-10-22 ssummer

melanoma

85 0
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2016-10-22 yinhl1980

#停药#

29 0
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2016-10-22 cqlidoudou

#黑色素#

31 0
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2016-10-22 cqlidoudou

#黑色素#

26 0

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Br J Cancer：靶向治疗后达到完全缓解的黑色素瘤患者，能停药吗？

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