Sci Rep:根治性膀胱切除术后不良心血管事件风险因素分析

2019-10-16 AlexYang MedSci原创

根治性膀胱切除术时肌肉浸润性膀胱肿瘤和非浸润性膀胱肿瘤的标准治疗方法,但是也伴随着高发生率的术后并发症,包括了严重的不良心血管事件(MACE)。舒张期功能障碍与术后并发症相关。最近,有研究人员评估了围手术期风险因素,包括了与术后6个月内与MACE有关的舒张期功能障碍。研究共包括了546名经历了选择根治性膀胱切除术的患者,研究发现,根治性膀胱切除术后6个月内,43(7.9%)名患者发展为MACE。M

根治性膀胱切除术时肌肉浸润性膀胱肿瘤和非浸润性膀胱肿瘤的标准治疗方法,但是也伴随着高发生率的术后并发症,包括了严重的不良心血管事件(MACE)。舒张期功能障碍与术后并发症相关。最近,有研究人员评估了围手术期风险因素,包括了与术后6个月内与MACE有关的舒张期功能障碍。

研究共包括了546名经历了选择根治性膀胱切除术的患者,研究发现,根治性膀胱切除术后6个月内,43(7.9%)名患者发展为MACE。MACE与女性性别(OR 2.546, 95%CI 1.166-5.557, P=0.019)和舒张期功能障碍(OR 3.077, 95%CI 1.147-8.252, P=0.026)相关。6个月的死亡率在MACE组中显著更高,并且住院时间和重症监护病房停留时间在MACE组中要比非MACE组显著更长。另外,术前舒张期功能障碍(E/e′>15)与术后MACE相关,而MACE与根治性膀胱切除术后6个月内的生存相关。

最后,研究人员指出,他们的结果表明了术前舒张期功能障碍能够为术后并发症提供有用的信息。

原始出处:


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