N Engl J Med:全国心肺血研究所数据库的使用情况 你造吗?

2017-06-20 应颖秋 环球医学资讯

2017年5月,发表在《N Engl J Med》的一项研究调查了全国心肺血研究所数据库的使用情况。 背景:临床试验数据分享的研究重点在于阐明试验者和研究受试者关于分享数据的看法、障碍和态度。然而,一旦临床试验数据得到广泛分享,很少有关于使用或相关文章出版方面的信息。

2017年5月,发表在《N Engl J Med》的一项研究调查了全国心肺血研究所数据库的使用情况。
背景:临床试验数据分享的研究重点在于阐明试验者和研究受试者关于分享数据的看法、障碍和态度。然而,一旦临床试验数据得到广泛分享,很少有关于使用或相关文章出版方面的信息。

方法:研究者分析了调查者对数据获取、出版物链接和文献计量学需求的官方记录,以描述全国心肺血研究所数据库的使用。

结果:从2000年1月至2016年5月,共有370例调查者需要1项或更多项试验的数据。对试验数据的需求量呈增长趋势,在研究期间的过去4年里,有195名(53%)调查者发起了数据需求。新问题的事后二次分析研究相关数据需求占主导(72%),其次是临床试验的分析或统计方法(9%)以及荟萃分析或合并研究(7%)。在172个有在线项目描述的需求中,仅有2个需求是为了获取对主要结局结果的再分析。在100个可获得的临床试验中,88个试验的数据至少被使用1次,从数据库的获取到首次使用的中位时间为235天。共有227篇文章基于47项试验的数据发表。224篇文章的引文指标显示,半数发表文章的累积引文达到主题范畴和发表年份最正常化的34%。

结论:研究者对用于二次分析的试验数据的需求正在攀升。用于对原始结果再次分析或验证的数据需求较为罕见。

原始出处:
Coady, S. A., et al. Use of the National Heart, Lung, and Blood Institute Data Repository.N Engl J Med. 2017 May 11;376(19):1849-1858. doi: 10.1056/NEJMsa1603542. Epub 2017 Mar 29.

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    2017-10-25 spoonycyy
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    2017-07-13 aids222
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    2018-05-17 haouestc
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