ACS Appl Mater Interfaces:诱导相变可有效增强氧化石墨烯的干细胞分化能力

2018-04-05 MedSci MedSci原创

氧化石墨烯(GO)由于其独特的二维性质和功能化学特性,在多个领域引起了研究人员极大的兴趣。然而,对于其在干细胞培养和分化的应用而言,GO通常被还原形成还原型氧化石墨烯,导致氧含量的损失。在这里,我们在GO中诱导相变并证明其在增强干细胞培养和分化中的益处,同时保持氧含量。该转化导致GO表面上的氧原子聚集,极大地提高了其对细胞粘附的能力并增强人间充质干细胞(hMSC)向成骨谱系的分化。此外,修饰过的G

氧化石墨烯(GO)由于其独特的二维性质和功能化学特性,在多个领域引起了研究人员极大的兴趣。然而,对于其在干细胞培养和分化的应用而言,GO通常被还原形成还原型氧化石墨烯,导致氧含量的损失。

在这里,我们在GO中诱导相变并证明其在增强干细胞培养和分化中的益处,同时保持氧含量。该转化导致GO表面上的氧原子聚集,极大地提高了其对细胞粘附的能力并增强人间充质干细胞(hMSC)向成骨谱系的分化。此外,修饰过的GO结合能力增强,辅助成骨生长肽缀合检测验证了这点。

总的来说,我们的工作证明了GO在干细胞应用中的潜力,同时保持其氧含量,这可实现进一步功能化并制造新型纳米生物界面。

原始出处:


Yang JW, Hsieh KY, et al., Enhanced Osteogenic Differentiation of Stem Cells on Phase-Engineered Graphene Oxide. ACS Appl Mater Interfaces. 2018 Mar 30. doi: 10.1021/acsami.8b02225. 

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    2018-04-07 yaanren
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    2018-04-05 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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    2018-04-05 虈亣靌

    优质资源.共同学习

    0

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