SCI REP:与慢性丙型肝炎患者肝细胞癌风险相关的临床疗效和治疗后血清标志物

2017-06-19 MedSci MedSci原创

我们的研究结果表明,在发展晚期纤维化之前治疗慢性丙型肝炎患者可以改善临床疗效,降低HCC风险。 此外,SVR患者仍需要连续监测HCC。

这项随访研究纳入慢性丙型肝炎患者,以评估治疗效果,并确定与持续病毒学应答(SVR)或非持续性病毒学应答(NSVR)患者的肝细胞癌(HCC)风险相关的治疗后期血清标志物。在2004 - 2013年期间共4639例患者接受聚乙二醇化干扰素和利巴韦林治疗,并随访到2014年12月。在26,163人年数的随访后,共报告233例HCC病例,表明每1000人年发病率为8.9例,SVR为6.9例,NSVR 为21.6例。与相对应的NSVR相比,对于没有肝硬化的患者,SVR患者的HCC相关风险为0.37(0.22-0.63),而有肝硬化患者,SVR患者的HCC相关风险为0.54(0.31-0.92)。SVR患者中,年龄高,男性性别,肝硬化,血小板减少,天冬氨酸氨基转移酶和甲胎蛋白含量升高均与HCC相关(p <0.001)。慢性丙型肝炎患者发生肝硬化之前的治疗效果比治疗已经发展为肝硬化的患者有更高的疗效。 患有SVR的患者可能仍然有HCC的风险,需要定期监测。

结论:我们的研究结果表明,在发展晚期纤维化之前治疗慢性丙型肝炎患者可以改善临床疗效,降低HCC风险。 此外,SVR患者仍需要连续监测HCC。

原文出处:

Chien-Jen Chen,et al.Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients.[J]Scientific Reports 7, Article number: 3718(2017),doi:10.1038/s41598-017-02313-y

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    2018-03-20 xjy02
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    2017-12-25 sjq027
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