J Toxicol:尼古丁或可预防脑老化

2016-09-26 MedSci MedSci原创

尼古丁香烟和电子烟液体里一种可让人成瘾性的化学物质,已知尼古丁有多个健康害处,但是据发表于Journal of Toxicology的一项新的研究表明,尼古丁或可防止脑老化。 既往动物和人类研究表明,尼古丁有益于机体的认知;可结合并激活大脑中的烟碱型乙酰胆碱受体(nAChR)在大脑中,研究已发现nAChR可减少神经退行性疾病。 然而,目前还不清楚这种关联的潜在机制,鉴于尼古丁的成瘾性质

尼古丁香烟和电子烟液体里一种可让人成瘾性的化学物质,已知尼古丁有多个健康害处,但是据发表于Journal of Toxicology的一项新的研究表明,尼古丁或可防止脑老化。

既往动物和人类研究表明,尼古丁有益于机体的认知;可结合并激活大脑中的烟碱型乙酰胆碱受体(nAChR)在大脑中,研究已发现nAChR可减少神经退行性疾病。

然而,目前还不清楚这种关联的潜在机制,鉴于尼古丁的成瘾性质考虑将其作为一种治疗神经退行性疾病的物质就不足为奇了。

本研究中,研究人员利用小鼠模型来观察不同剂量对尼古丁食欲,体重,焦虑,和大脑中nAChRs水平的影响。

研究人员在小鼠的饮用水中添加了低、中、高剂量的尼古丁。

在评估接受低、中剂量尼古丁的小鼠时,研究人员发现其血液中无尼古丁残留,且小鼠的食物摄入量、体重或nAChRs的水平并无变化。

然而,接受高剂量尼古丁的小鼠,其食物摄入量和体重减少,而胆碱受体的水平增加。此外,研究人员发现高剂量小鼠中并没有出现焦虑增加的迹象。

研究人员表示他们计划下一步探究尼古丁对老年小鼠神经退行性疾病的影响,并确定是否尼古丁减少食欲和增加体重的作用是否可解释其对脑老化的抵抗作用。

然而,目前的研究结果表明,尼古丁治疗是不太可能会改变行为,使得研究人员进一步探究尼古丁作为治疗神经退行性疾病的安全性。

研究人员强调该研究发现不应鼓励使用香烟和其他含有尼古丁的产品。研究并没有证明这种上瘾的药物是安全的,而且它肯定不能应用于童年或青春期,且也不能认为 尼古丁的益处大于其潜在的风险。

即使没有本研究的初步结果,吸烟所导致的如此多的健康问题使得尼古丁的任何益处也变得微不足道,然而,吸烟只是管理尼古丁的一种潜在的方式,该研究表明我们不应该完全戒掉尼古丁。

原始出处:

Honor Whiteman. Nicotine has the potential to prevent brain aging, study suggests. 26 September 2016.

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    2016-10-01 jaysppr

    好文章,受益颇多!

    0

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    2016-09-27 舒心和人

    如果没记错的话砒霜可以治疗m3型白血病,但总不能鼓励天天把砒霜当饭吃吧

    0

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    2016-09-26 知难而进

    继续关注!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=138525, encodeId=a58813852587, content=好文章,受益颇多!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sat Oct 01 13:43:18 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387995, encodeId=274a138e995a5, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Wed Sep 28 02:50:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135764, encodeId=b341135e6480, content=如果没记错的话砒霜可以治疗m3型白血病,但总不能鼓励天天把砒霜当饭吃吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 27 10:23:32 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135623, encodeId=88a413562372, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Mon Sep 26 21:33:19 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135622, encodeId=e8fd1356223d, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Mon Sep 26 21:33:09 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135403, encodeId=860713540306, content=等待进一步研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Sep 26 12:41:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135395, encodeId=7672135395e6, content=搞笑,我不认同, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd381919282, createdName=1e0a2178m68(暂无匿称), createdTime=Mon Sep 26 12:17:00 CST 2016, time=2016-09-26, status=1, ipAttribution=)]
    2016-09-26 知难而进

    谢谢分享!

    0

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    2016-09-26 oo902

    等待进一步研究

    0

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    2016-09-26 1e0a2178m68(暂无匿称)

    搞笑,我不认同

    0

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