Int J Epidemiol:成年时期身体质量指数轨迹和抽烟与前列腺癌风险相关

2018-11-11 AlexYang MedSci原创

之前,有研究人员展示了成年时期身体质量指数(BMI)轨迹能够导致肥胖,并且与致死的前列腺癌(PCA)风险的增加有关。为了进一步探索之前的关系,研究人员进行了一个NIH-AARP饮食和健康研究。研究总共包括了153730名符合标准且募集到NIH-AARP群体中的男性,实践为1995年到1996年(平均跟踪调查时间为15.1年),研究人员鉴定了630个致死的PCA案例和16896个发生的案例,并在18

之前,有研究人员展示了成年时期身体质量指数(BMI)轨迹能够导致肥胖,并且与致死的前列腺癌(PCA)风险的增加有关。为了进一步探索之前的关系,研究人员进行了一个NIH-AARP饮食和健康研究。

研究总共包括了153730名符合标准且募集到NIH-AARP群体中的男性,实践为1995年到1996年(平均跟踪调查时间为15.1年),研究人员鉴定了630个致死的PCA案例和16896个发生的案例,并在18岁、35岁和50岁时对BMI分别进行了评估。研究发现,研究中的BMI(平均年龄=63,HR=1.12; 95% CI=1.01, 1.24, per 5-unit increase)和成年时期最大BMI(HR=1.12; 95% CI=1.02, 1.24, per 5-unit increase)均与致死性PCA风险的增加相关。抽烟的情况调整了BMI轨迹与致死性PCA之间的关系。在从不抽烟者中,与维持正常体重轨迹的患者相比,正常体重到肥胖的BMI轨迹与致死性疾病风险的增加相关(HR=2.37; 95% CI=1.38, 4.09),然而与之前抽烟还是现在抽烟没有关系。另外,在所有的年龄中,总的非恶性PCA展现出了与BMI的负相关关系,而恶性PCA没有上述相关性。

最后,研究人员指出,BMI的增加与致死性PCA具有正相关关系,尤其是那些从不抽烟的人群中。

原始出处:


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    2019-02-13 sjq027
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    2018-11-13 gujh
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    2018-11-11 1dd8a7c5m95(暂无匿称)

    认真学习,不断进步,把经验分享给同好。点赞了!

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    2018-11-11 医者仁心5538

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