Diabetes Obes Metab:早年生活抗生素暴露与儿童超重和肥胖!

2018-01-26 xing.T MedSci原创

总之,婴儿期接受抗生素治疗与儿童超重和肥胖风险略有增加有关,主要是儿童在生命的头六个月内是否接受抗生素治疗以及是否接受重复治疗。这种相关性是否是抗生素通过对肠道微生物群的直接作用来介导仍然是不明确的。

近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇荟萃分析文章。研究人员对分析婴儿期抗生素暴露与儿童超重和肥胖风险之间相关性的观察性研究进行了系统回顾和荟萃分析。

研究人员通过检索了相关的数据库将13项研究共计527504名儿童纳入了系统评价,并将8项纳入了荟萃分析。

研究人员发现婴儿期接触抗生素与儿童超重和肥胖的比值比(OR)增加有关(OR为1.11 [95%可信区间为1.02-1.20])。然而只接受一次抗生素治疗和在6-24个月期间接受抗生素治疗与儿童期超重和肥胖的风险增加无关,接受抗生素治疗一次以上与儿童超重和肥胖的比值比为1.24(95%可信区间为1.09-1.43)和出生前六个月内接受抗生素治疗与儿童超重和肥胖的比值比为1.20(95%可信区间为1.04-1.37)。

总之,婴儿期接受抗生素治疗与儿童超重和肥胖风险略有增加有关,主要是儿童在生命的头六个月内是否接受抗生素治疗以及是否接受重复治疗。这种相关性是否是抗生素通过对肠道微生物群的直接作用来介导仍然是不明确的。

原始出处:


Sara H Rasmussen,et al. Antibiotic exposure in early life and childhood overweight and obesity: A systematic review and meta-analysis. Diabetes Obesity & Metabolism.2017. http://onlinelibrary.wiley.com/doi/10.1111/dom.13230/full

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    2018-03-06 仁者大医
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    2018-06-25 一闲
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    2018-02-03 15991890016白熊

    儿童是祖国的未来.不得胡乱使用抗生素.应多向孩子家人普及一下知识

    0

  7. 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    2018-01-29 Ramsey

    抗生素在儿童期的确应该好好管理

    0

  8. 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    2018-01-26 139****0239

    henhao

    0

  9. 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    2018-01-26 changjiu

    学习一下谢谢

    0

  10. 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    2018-01-26 131****1460

    学习了受益匪浅

    0

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