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药物公司转向调节T细胞治疗自身免疫性疾病研究

2017-08-04 MedSci MedSci原创

调节T细胞研究自身免疫性疾病
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学术界和产业界的研发人员掀起了调节性T细胞的研发热潮，以期通过免疫抑制细胞抑制自身免疫性疾病。7月24日，位于美国印第安纳州印第安纳波利斯市的礼来公司宣布将支付4亿美元来支持开发一种刺激调节性T细胞的药物，该药物在3月份进入临床试验阶段。1月份，新基生物医药公司（Celgene）宣布计划以3亿美元的价格收购一家做类似药物的公司。T细胞通常被认为是免疫系统对抗外来入侵者的关键步兵。但T细胞种类繁多，

学术界和产业界的研发人员掀起了调节性T细胞的研发热潮，以期通过免疫抑制细胞抑制自身免疫性疾病。7月24日，位于美国印第安纳州印第安纳波利斯市的礼来公司宣布将支付4亿美元来支持开发一种刺激调节性T细胞的药物，该药物在3月份进入临床试验阶段。1月份，新基生物医药公司（Celgene）宣布计划以3亿美元的价格收购一家做类似药物的公司。T细胞通常被认为是免疫系统对抗外来入侵者的关键步兵。但T细胞种类繁多，且各司其职。调节性T细胞可以抑制免疫反应，而不是攻击入侵者，对预防自身免疫很重要。由自身免疫系统攻击引起的疾病的人通常其调节T细胞的水平降低，因此科学家们猜测增强这些细胞可以降低免疫系统对自身的侵袭。为了增强这类细胞的作用，许多研究人员--包括礼来和新基公司--将目标转向白介素-2（IL-2）。高剂量的IL-2可以刺激效应T细胞清除外来物质。1992年美国监管部门批准IL-2用于癌症的治疗，通过免疫应答对抗肿瘤。但是低剂量的IL-2--低于癌症治疗剂量的10倍--可以刺激调节性T细胞，且对效应T细胞的作用相对较小。这一现象发现于20世纪，但一些研究人员拒绝使用IL-2来治疗自身免疫性疾病，即使

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    2017-10-30 zhanfl

    #调节T细胞#

    0

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    2018-01-24 heli0118

    #疾病研究#

    0

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    2017-08-06 124988c7m100暂无昵称

    #免疫性疾病#

    0

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    2017-08-05 龙胆草

    学习谢谢分享

    0

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    2017-08-05 龙胆草

    学习谢谢分享

    0

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    2017-08-05 130****4638

    学习了受益匪浅

    0

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    2017-08-05 changjiu

    学习了，谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1696231, encodeId=0b541696231ab, content=<a href='/topic/show?id=d4a092049c8' target=_blank style='color:#2F92EE;'>#调节T细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92049, encryptionId=d4a092049c8, topicName=调节T细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5129877228, createdName=zhanfl, createdTime=Mon Oct 30 22:29:00 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070416, encodeId=5a2c20e041650, content=<a href='/topic/show?id=f30de0713e1' target=_blank style='color:#2F92EE;'>#疾病研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70713, encryptionId=f30de0713e1, topicName=疾病研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Jan 24 18:29:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580127, encodeId=175c158012ecb, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Sun Aug 06 12:29:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230209, encodeId=c6c223020982, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 05 07:05:34 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230208, encodeId=27c723020815, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 05 07:05:17 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230171, encodeId=94352301e11c, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Aug 05 06:22:23 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230146, encodeId=dc49230146c6, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Aug 05 05:18:33 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230085, encodeId=26a223008593, content=T细胞通常被认为是免疫系统对抗外来入侵者的关键步兵。但T细胞种类繁多，且各司其职。调节性T细胞可以抑制免疫反应，而不是攻击入侵者，对预防自身免疫很重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Aug 04 23:05:12 CST 2017, time=2017-08-04, status=1, ipAttribution=)]
    2017-08-04 有备才能无患

    T细胞通常被认为是免疫系统对抗外来入侵者的关键步兵。但T细胞种类繁多，且各司其职。调节性T细胞可以抑制免疫反应，而不是攻击入侵者，对预防自身免疫很重要。

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