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Cancer Sci：肿瘤和血清中的LRG1或可用于胃癌患者的预后分析

2017-10-11 MedSci MedSci原创

LRG1胃癌
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胃癌是最常见的恶性肿瘤之一。尽管化疗有所改善，但晚期胃癌的临床预后依然很差。因此，预测预后越来越重要，并且确定患者是否应该接受新辅助化疗或辅助化疗。富含亮氨酸的α2-糖蛋白-1（LRG 1）在炎症过程中过表达，与各种恶性肿瘤有关。在本研究中，我们评估癌症标本和癌症患者血清中的LRG 1表达，以阐明LRG 1作为胃癌生物标志物的有效性。本研究纳入239例（免疫组织化学染色; IHC）和184例（EL

胃癌是最常见的恶性肿瘤之一。尽管化疗有所改善，但晚期胃癌的临床预后依然很差。因此，预测预后越来越重要，并且确定患者是否应该接受新辅助化疗或辅助化疗。富含亮氨酸的α2-糖蛋白-1（LRG 1）在炎症过程中过表达，与各种恶性肿瘤有关。

在本研究中，我们评估癌症标本和癌症患者血清中的LRG 1表达，以阐明LRG 1作为胃癌生物标志物的有效性。本研究纳入239例（免疫组织化学染色; IHC）和184例（ELISA））胃癌患者。IHC的结果表明LRG 1表达与组织学类型，淋巴和静脉浸润，肿瘤和结节以及疾病阶段显著相关。高LRG 1表达组的总体生存率显著低于低LRG 1组（P = 0.0003）。

总体生存率的Cox多变量分析显示，LRG 1表达是独立预后因子（P = 0.0258）。胃癌患者血清LRG1明显高于健康志愿者，且随病理进展而增加。此外，IHC血清LRG 1水平与LRC1表达显著相关（P < 0.0001）。抑制LRG1能显著降低体外细胞增殖（胃癌细胞转移和浸润能力）。

总之，这些结果表明，肿瘤和血清中的LRG1表达可能是胃癌患者中有用的预后标志物。

原始出处：

Masaaki Yamamoto,  Tsuyoshi Takahashi, et al., Overexpression of leucine‐rich α2‐glycoprotein‐1 is a prognostic marker and enhances tumor migration in gastric cancer. Cancer Sci. 2017 Oct; 108(10): 2052–2060. Published online 2017 Oct 2. doi:  10.1111/cas.13329

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    2018-07-06 huhuaidong400

    #胃癌患者#

    0

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    2017-10-16 yunger

    有前景的技术

    0

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    2017-10-13 Drhzm308

    谢谢了.学习了

    0

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    2017-10-12 明月清辉

    谢谢分享.学习了

    0

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    2017-10-12 龙胆草

    学习谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1769645, encodeId=3dd31e69645f6, content=<a href='/topic/show?id=900b8323461' target=_blank style='color:#2F92EE;'>#胃癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83234, encryptionId=900b8323461, topicName=胃癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=377c38086944, createdName=huhuaidong400, createdTime=Fri Jul 06 13:44:00 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253298, encodeId=15e4253298f9, content=有前景的技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Mon Oct 16 06:56:02 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252466, encodeId=6c50252466ee, content=谢谢了.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Fri Oct 13 08:08:15 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252152, encodeId=e691252152d2, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Oct 12 07:03:16 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252131, encodeId=2ab62521319b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Oct 12 06:46:02 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252091, encodeId=1e1925209176, content=阅读.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Oct 12 05:38:50 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252070, encodeId=99262520e0f1, content=血清学预后分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Thu Oct 12 00:06:22 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252061, encodeId=516c25206105, content=不错的文章值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Oct 11 23:15:53 CST 2017, time=2017-10-11, status=1, ipAttribution=)]
    2017-10-12 刘煜

    阅读.谢谢分享.

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1769645, encodeId=3dd31e69645f6, content=<a href='/topic/show?id=900b8323461' target=_blank style='color:#2F92EE;'>#胃癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83234, encryptionId=900b8323461, topicName=胃癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=377c38086944, createdName=huhuaidong400, createdTime=Fri Jul 06 13:44:00 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253298, encodeId=15e4253298f9, content=有前景的技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Mon Oct 16 06:56:02 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252466, encodeId=6c50252466ee, content=谢谢了.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Fri Oct 13 08:08:15 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252152, encodeId=e691252152d2, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Oct 12 07:03:16 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252131, encodeId=2ab62521319b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Oct 12 06:46:02 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252091, encodeId=1e1925209176, content=阅读.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Oct 12 05:38:50 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252070, encodeId=99262520e0f1, content=血清学预后分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Thu Oct 12 00:06:22 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252061, encodeId=516c25206105, content=不错的文章值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Oct 11 23:15:53 CST 2017, time=2017-10-11, status=1, ipAttribution=)]
    2017-10-12 llaq

    血清学预后分析

    0

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    2017-10-11 1e1b8538m79(暂无匿称)

    不错的文章值得一读

    0