Am J Kidney Dis:急性肾损伤可预测战斗伤员死亡情况

2016-10-05 xing.T MedSci原创

由此可见,AKI可预测在伊拉克和阿富汗的战争中受伤的老兵死亡情况。

急性肾损伤(AKI)已被证实与创伤死亡率相关,然而,缺乏军事人员在战斗中受创伤后肾功能状况的数据。近日,肾脏病领域权威杂志《Am J Kidney Dis》上发表了来自美国特拉维斯空军基地David Grant医疗中心的Ian J. Stewart军医及其团队的研究文章,试图明确战斗创伤的士兵发生AKI的危险因素并探讨AKI能否作为死亡率的预测因素。

该研究为回顾性观察研究,研究者纳入了从2002年2月1日到2011年2月1日期间在伊拉克或阿富汗服役的危重伤员,这些伤员在后撤至德国兰施图尔地区医疗中心过程中尚存活。在损伤初期统计伤员人口学资料、生命体征、损伤严重程度评分、烧伤、损伤机制,以及通过利用KDIGO(肾脏疾病:改善全球预后)血清肌酐标准在创伤最初7天明确AKI的存在。研究者采用Logistic回归模型来确定AKI和死亡的危险因素。

研究者共分析了6011例伤员记录,排除丢失数据的伤员,还有3807例伤员进入下一轮研究。研究者发现474例(12.5%)伤员发生AKI,112例(2.9%)伤员发生死亡,相比于未发生AKI的伤员,更多的AKI患者出现死亡(N=62 [13.1%] vs N=50 [1.5%];P < 0.001)。调整后,AKI可作为死亡的预测因素(OR未5.14;95%可信区间为3.33-7.93;P < 0.001)。AKI的预测因素包括年龄、非洲裔美国人、损伤严重程度评分、截肢、烧伤。

由此可见,AKI可预测在伊拉克和阿富汗的战争中受伤老兵死亡情况。

原始出处:


Ian J. Stewart, et al. Acute Kidney Injury in Critically Injured Combat Veterans: A Retrospective Cohort Study. Am J Kidney Dis.2016;

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    2016-10-07 gwc389
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    2016-10-05 1e0d99ddm02(暂无匿称)

    了解一下!

    0

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    2016-10-05 1e0d99ddm02(暂无匿称)

    学习了,分享一下!

    0

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