Neurology:注意力缺陷/多动障碍药物治疗可降低患者癫痫发作风险

2018-02-24 zhangfan MedSci原创

研究发现,接受注意力缺陷/多动障碍药物治疗可降低患者癫痫发作风险,该效果不受先前癫痫发作史的影响

统计发现患有注意力缺陷/多动障碍(ADHD)人群癫痫发作的风险增加,但目前尚不清楚ADHD药物治疗对癫痫风险的影响。

研究对801838名ADHD患者及其药物治疗情况进行考察,探讨ADHD药物治疗对癫痫的影响。首先,研究人员考察了ADHD患者中总的癫痫发病率,之后考察患者在接受药物治疗期间的癫痫发病率,最终考察癫痫发作与过去2年间药物治疗的相关性。

研究发现,ADHD患者其任何类型的癫痫风险显著提高(男性OR=2.33,女性OR=2.31)。内部比较调整后,对于之前有癫痫发作史的患者,ADHD药物治疗可减少患者癫痫复发风险(OR = 0.71, 95% CI = 0.60–0.85) ,而对于之前无癫痫发作史的患者,ADHD治疗同样有效(OR = 0.71, 95% CI = 0.62–0.82)。长期内部比较认为,无证据表明ADHD治疗可导致有(OR = 0.87, 95% CI = 0.59–1.30)或无 (OR = 1.01, 95% CI = 0.80–1.28)癫痫发作史患者癫痫复发风险增加。

研究发现,接受注意力缺陷/多动障碍药物治疗可降低患者癫痫发作风险,该效果不受先前癫痫发作史的影响。

原始出处:

Kelsey K. Wiggs et al. Attention-deficit/hyperactivity disorder medication and seizures.Neurology. February 23, 2018.

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    2018-11-18 yinhl1978
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    2018-02-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2018-02-24 龙胆草

    学习谢谢分享

    0

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    2018-02-24 wzb521zf

    一起学习学习

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    2018-02-24 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0