JAMA Neurol:视神经变性与痴呆的相关性研究

2018-06-26 zhangfan MedSci原创

研究发现,视网膜神经纤维层薄导致痴呆以及阿尔兹海默风险增加,视网膜神经变性可作为痴呆的临床前生物标志物

视网膜结构可能反映老年人群的认知情况,近日研究人员就视网膜内层厚度与痴呆风险之间的关系进行了考察。

2007-12年间,45岁以上基线无中风、帕金森病、多发性硬化症、青光眼、黄斑变性、视网膜病变、近远视、视盘病人群接受视网膜光学相干断层扫描,以测量视网膜层 (视网膜神经纤维层[RNFL])和神经节细胞-内丛状层(GC-IPL)厚度,随访至2015年。研究的主要终点是视网膜层厚度每降低1个SD导致的痴呆风险。

3289名参与者,平均年龄68.9岁,女性占57%,其中41人(1.2%)基线痴呆。研究发现基线GC-IPL较薄人群的痴呆风险增加,GC-IPL每减少1SD的痴呆风险为1.37,但基线RNFL与基线痴呆无关。在14674个随访年中,总计86人发展为痴呆(2.6%),其中68人患AD,基线较薄的RNFL增加后继痴呆风险,RNFL每减少1个SD的痴呆风险为1.44,AD风险为1.43,基线GC-IPL与后继痴呆风险无关。

研究发现,视网膜神经纤维层薄导致痴呆以及阿尔兹海默风险增加,视网膜神经变性可作为痴呆的临床前生物标志物。

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    2019-08-20 chenxh201314

    眼科威武

    0

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    2018-07-10 yinhl1978
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Jun 26 13:15:16 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327152, encodeId=946732e15245, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Jun 26 13:15:12 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327146, encodeId=422432e14660, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Tue Jun 26 13:02:24 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-08-23 gj0740
  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Jun 26 13:15:16 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327152, encodeId=946732e15245, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Jun 26 13:15:12 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327146, encodeId=422432e14660, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Tue Jun 26 13:02:24 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-28 huangdf
  6. 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  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Tue Jun 26 13:02:24 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 wzb521zf

    一起学习学习

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Jun 26 13:15:16 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327152, encodeId=946732e15245, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Jun 26 13:15:12 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327146, encodeId=422432e14660, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Tue Jun 26 13:02:24 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 医者仁心5538

    学习了

    0

  9. 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topicName=null, topicId=null, topicList=[TopicDto(id=74245, encryptionId=d785e42454f, topicName=神经变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d72417807199, createdName=mfx805, createdTime=Thu Jun 28 03:57:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327168, encodeId=c50732e1680e, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jun 26 13:37:19 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327151, encodeId=6f6d32e151ee, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Tue Jun 26 13:02:24 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 惠映实验室

    学习了.谢谢分享.

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Jun 26 13:15:16 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327152, encodeId=946732e15245, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Jun 26 13:15:12 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327146, encodeId=422432e14660, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Tue Jun 26 13:02:24 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 1201e5c5m39暂无昵称

    学习了

    0

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