BMC子刊:荟萃分析-剖宫产可降低我国乙肝母婴传播风险

2017-09-17 佚名 国际肝病网

母婴传播(MTCT)是乙型肝炎病毒(HBV)的主要传播途径,然而迄今为止,尚不清楚分娩方式是否会影响HBV的母婴传播。近日,我国学者发表的一篇荟萃分析显示:相比于阴道分娩,剖宫产可以降低我国的HBV母婴传播风险。


母婴传播(MTCT)是乙型肝炎病毒(HBV)的主要传播途径,然而迄今为止,尚不清楚分娩方式是否会影响HBV的母婴传播。近日,我国学者发表的一篇荟萃分析显示:相比于阴道分娩,剖宫产可以降低我国的HBV母婴传播风险。

研究者对PubMed(Medline)、Embase、ISI 科学网、中国生物医学文献数据库、中国国家知识基础设施和中国科技期刊数据库进行了系统的文献检索。收集分析分娩方式对HBV母婴传播影响的随机对照试验、队列研究或病例-对照研究。

结果,共纳入了包含30个数据集的28篇文章,包括9906名参与者。总体而言,HBV的母婴传播率为6.76%(670/9906),行剖宫产手术者为4.37%(223/5105),经阴道分娩者为9.31%(447/4801)。总体相对危险度(RR)为0.51(95%:0.44:0~0.60,P<0.001),这提示,相比于经阴道分娩,行剖宫产术者的HBV垂直传播率显著下降具有统计学意义。

这些研究具有中等异质性,I2为29%。Egger's和Begg's检验均未发现发表性偏倚,倒漏斗图显示对称。亚组分析显示,母体乙型肝炎e抗原状态和随访时间并不影响结果,但乙型肝炎免疫球蛋白 (HBIG)管理对母亲和婴儿有意义。

以上分析结果提示:在我国,与阴道分娩相比,剖宫产可以降低HBV的母婴传播风险。但作者也提到:“由于我们的荟萃分析具有局限性,未来可能还是需要设计良好的随机对照试验来证实。”


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    2017-11-04 zhaojie88
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    2018-03-26 柳叶一刀
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    2017-09-20 虈亣靌

    学习一下很不错

    0

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    2017-09-19 zhouqu_8
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    2017-09-18 妇产软妹子

    0

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    2017-09-18 蔬菜

    好东西.学习了学习了

    0

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