Sci Rep:lncRNA-p53调控网络的基因多态性或可改善鼻咽癌患者的预后

2017-09-09 MedSci MedSci原创

转录因子p53与癌症的相关性是不容争辩的,很多lncRNAs作为调控者或者被调控者参与了p53调控网络,引发转录反应,导致细胞周期阻滞和凋亡。尽管鼻咽癌的治疗反应有所改善,但是患者之间的异质性仍然会影响患者对不良反应的易感性和治疗效果。本研究中,研究人员共纳入了505例鼻咽癌患者,分析了lncrna-p53调控网络中五个基因的八个潜在的功能SNPs。通过多因素logistic回归分析,研究了遗传变

转录因子p53与癌症的相关性是不容争辩的,很多lncRNAs作为调控者或者被调控者参与了p53调控网络,引发转录反应,导致细胞周期阻滞和凋亡。尽管鼻咽癌的治疗反应有所改善,但是患者之间的异质性仍然会影响患者对不良反应的易感性和治疗效果。

本研究中,研究人员共纳入了505例鼻咽癌患者,分析了lncrna-p53调控网络中五个基因的八个潜在的功能SNPs。通过多因素logistic回归分析,研究了遗传变异对CRT诱导毒性的疗效和风险的影响。最引人注目的是,MEG3 rs10132552 CC基因型患者3- 4级贫血的风险增三倍多(OR  = 3.001,95% CI = 1.355–6.646,P = 0.007  )。此外,rs10132552 CT基因型对治疗的反应较好(OR  = 0.261,95% CI = 0.089–0.770,P = 0.015  )。携带LINC-ROR rs2027701的患者伴有一个或两个等位基因变异与中性粒细胞减少的风险降低密切相关(OR = 0.503,95% CI = 0.303–0.835,P = 0.008  )。

总之,我们的研究结果表明,lncRNA-p53调控网络的基因多态性可减少治疗相关的毒性反应,并改善鼻咽癌患者的预后。

原始出处:

Youhong Wang, Zhen Guo, et al., Genetic polymorphisms of lncRNA-p53 regulatory network genes are associated with concurrent chemoradiotherapy toxicities and efficacy in nasopharyngeal carcinoma patients. Sci Rep. 2017; 7: 8320. Published online 2017 Aug 16. doi: 10.1038/s41598-017-08890-2

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    2017-09-11 方舒

    学习

    0

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    2017-09-11 xzw113
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    2017-09-11 zhishijing
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    2017-09-11 xzw120
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    2017-09-10 明月清辉

    谢谢分享.学习了

    0

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    2017-09-10 忠诚向上

    好好学习.多看看

    0

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