CLIN CANCER RES:ACYP2和WFS1药物基因组学改变在睾丸癌患者顺铂诱导的耳毒性中发挥的作用

2018-04-26 MedSci MedSci原创

约五分之一接受顺铂治疗的成人患者会出现药物不良反应,如耳毒性。这会给患者增加巨大的社会经济学负担,尤其是在成人早期发展的睾丸癌患者。近期的基因组相关研究发现ACYP2和WFS1基因改变与顺铂诱导的耳毒性有关。CLIN CANCER RES近期发表了一篇文章,研究睾丸癌患者中这些基因易感因素与顺铂诱导的耳毒性中发挥的作用。 作者收集了229例接受顺铂治疗的睾丸癌患者的临床和人口学数据。患者进行两种

约五分之一接受顺铂治疗的成人患者会出现药物不良反应,如耳毒性。这会给患者增加巨大的社会经济学负担,尤其是在成人早期发展的睾丸癌患者。近期的基因组相关研究发现ACYP2和WFS1基因改变与顺铂诱导的耳毒性有关。CLIN CANCER RES近期发表了一篇文章,研究睾丸癌患者中这些基因易感因素与顺铂诱导的耳毒性中发挥的作用。


作者收集了229例接受顺铂治疗的睾丸癌患者的临床和人口学数据。患者进行两种基因型检测,ACYP2 rs1872328和WFS1 rs62283056,之前报道过与顺铂治疗患者听力丧失有关。在睾丸癌成人队列中分析分析这些基因型与耳毒性之间的关系。研究结果表明,ACYP2 rs1872328与顺铂诱导的耳毒性显著相关。WFS1 rs62283056与顺铂导致的耳毒性无显著相关性,但是这一因素与任何原因导致的听力丧失有关。

文章最后认为,该研究第一次阐述了ACYP2 rs1872328在顺铂诱导的耳毒性中发挥的作用。这一结果可以用于指导预防顺铂诱导的耳毒性的治疗策略的发展。此外,该研究进一步强调了之前研究发现的基因差异的重要性,为WFS1 rs62283056在听力丧失易感性方面提供了证据。

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    2018-04-28 zhangph
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    2018-04-27 kafei

    了解一下谢谢

    0

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