Eur J Cancer：卵巢癌患者预后因素研究

2016-08-30 Moon 译 MedSci原创

通过对晚期卵巢上皮癌无进展生存率(PFS)和总生存（OS）预后因素相关的III期前瞻性随机对照临床试验的荟萃数据（涉及四项研究：AGO、GINECO、NSGO、AGO-OVAR）进行了分析，评估年轻卵巢癌患者的预后因素。来自四项前瞻性研究的5055名患者进行了分析，其中294名年龄小于40岁，4761名患者年龄大于等于40岁。我们进行了生存分析和Cox比例风险回归模型，以及405名浆液性卵

通过对晚期卵巢上皮癌无进展生存率(PFS)和总生存（OS）预后因素相关的III期前瞻性随机对照临床试验的荟萃数据（涉及四项研究：AGO、GINECO、NSGO、AGO-OVAR）进行了分析，评估年轻卵巢癌患者的预后因素。

来自四项前瞻性研究的5055名患者进行了分析，其中294名年龄小于40岁，4761名患者年龄大于等于40岁。我们进行了生存分析和Cox比例风险回归模型，以及405名浆液性卵巢癌上皮、具有良好的性能状态、接受了肿瘤细胞减灭术和≥5次化疗的患者进行一致性良好的子集分析。

数据显示，对于小于40岁的患者，中位数PFS和OS分别为28.9个月和75.3个月；对于大于等于40岁患者，以上两个值分别为18.1个月和45.7个月。两个不同年龄组间的独立预测因素是相似的。校正包括可能导致混淆的预后因素后的多变量分析显示，年龄更小与PFS(HR, 0.86; 95% CI: 0.72-1.03) 、OS的改善有关(HR, 0.73; 95% CI: 0.59-0.91)。对接受合适治疗的浆液性卵巢癌上皮患者子集分析中，观察到了更强烈的影响PFS (HR, 0.34; 95% CI: 0.19-0.59)、OS (HR, 0.23; 95% CI: 0.09-0.56)。

结果表明，40岁作为年龄阈值，两个年龄组的预后因素是相似的；“年轻”似乎是PFS和OS的强大的独立预后因素。

原始出处：

Klar M.et al.Prognostic factors in young ovarian cancer patients: An analysis of four prospective phase III intergroup trials of the AGO Study Group, GINECO and NSGO.Eur J Cancer. 2016 Aug 22;66:114-124. doi: 10.1016/j.ejca.2016.07.014. [Epub ahead of print]

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2017-03-10 bnurmamat

#患者预后#

31 0
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2016-09-26 1e10c84am36(暂无匿称)

文章很好值得关注

86 0
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2016-09-25 ylzr123

赞了！深度好文，深入学习。

65 0
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2016-09-05 李东泽

很好，不错，以后会多学习

73 0
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2016-09-01 李东泽

很好，不错，以后会多学习

66 0
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2016-09-01 ms2536978994064944

#预后因素#

20 0
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2016-08-31 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

52 0
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2016-08-31 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

0 0
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createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 10:22:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108085, encodeId=348c10808584, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 10:21:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
2016-08-31 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

30 0
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createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 26 09:33:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134700, encodeId=703c134e004c, content=赞了！深度好文，深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 25 07:07:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111385, encodeId=6cb611138583, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 10:43:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108886, encodeId=b6c9108886a3, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 01 13:03:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479272, encodeId=55fb14e927247, content=<a href='/topic/show?id=8c141001e8c6' target=_blank style='color:#2F92EE;'>#预后因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100178, encryptionId=8c141001e8c6, topicName=预后因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49d37510120, createdName=ms2536978994064944, createdTime=Thu Sep 01 06:02:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108102, encodeId=ad4810810226, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 10:23:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), 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createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 10:22:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108085, encodeId=348c10808584, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 10:21:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
2016-08-31 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

28 0

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