Diabetes Care:研究确定导致2型糖尿病的又一大“祸根”,比遗传因素还可怕!

2018-02-13 佚名 medicalxpress

一项新的研究深入研究了轮班工作和2型糖尿病之间的联系。布里格姆妇女医院的调查人员利用英国生物银行数十万人的数据,更好地了解轮班工作,尤其是频繁的夜班工作如何导致2型糖尿病的发生。该小组还为2型糖尿病制定了遗传风险评分,对数据库中数万名工人的遗传数据进行了检查。他们发现,更频繁的夜班工作增加了2型糖尿病的患病几率。他们的研究结果发表在《糖尿病护理》杂志上。

一项新的研究深入研究了轮班工作和2型糖尿病之间的联系。布里格姆妇女医院的调查人员利用英国生物银行数十万人的数据,更好地了解轮班工作,尤其是频繁的夜班工作如何导致2型糖尿病的发生。该小组还为2型糖尿病制定了遗传风险评分,对数据库中数万名工人的遗传数据进行了检查。他们发现,更频繁的夜班工作增加了2型糖尿病的患病几率。他们的研究结果发表在《糖尿病护理》杂志上。

研究人员指出:“我们发现夜班工作频率和2型糖尿病之间存在剂量反应关系,人们越频繁地轮班工作,患这种疾病的可能性就越大,不管遗传倾向如何,这有助于我们理解其中的一个难题:夜班工作频率似乎是一个重要因素。”

研究小组审查了来自270000多人的数据,其中70000人提供了终身就业信息,另有44000多个群体提供了遗传数据。样本人群中有6000多人患有2型糖尿病。研究小组利用100多个与2型糖尿病相关的基因变异的信息,开发了一个遗传风险评分,他们用来给每个参与者指定一个值。正如预期的那样,那些遗传风险得分最高的人患2型糖尿病的可能性几乎是遗传风险分数较低的个体的四倍。

研究小组发现,与日间工人相比,所有轮班工人都更容易患2型糖尿病,除了长期夜班工人外。在考虑到其他已确定的危险因素后,那些不定时轮班和通常夜班工作的人患2型糖尿病的可能性高出44%。

“我们的结果表明,这两个危险因素都在2型糖尿病的可能性中发挥作用,我们发现这两种2型糖尿病危险因素之间似乎没有相互作用,这是一种新的发现,需要在今后的研究中运用,特别是在其他血统的人群中。”

原始出处:

Céline Vetter, Hassan S. Dashti, Jacqueline M. Lane, et.al. Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank. Diabetes Care 2018 Feb

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    2018-02-26 惠映实验室

    学习.谢谢分享.

    0

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    2018-02-17 大爰

    学习了谢谢分享!!

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