J Biomed Mater Res A:多级宏观/介孔结构对成骨细胞样细胞反应的影响

2018-03-13 MedSci MedSci原创

为了提高医疗器械的成功率,迫切需要具有强表面生物活性的植入物。由微弧氧化(MAO)产生的具有大孔结构的涂层具有优点,例如与基材的强粘合性和优异的抗磨损和耐腐蚀性。中孔结构含有2-50nm大小的孔隙,可赋予生物材料增强骨形成的能力,并可装载多种药物。因此,在这项研究中,我们旨在评估大孔和介孔结构使用分级宏/中孔结构修饰钛种植体表面的影响。研究探究了SaOS-2骨肉瘤细胞在宏观/介孔结构上的行为,包括

为了提高医疗器械的成功率,迫切需要具有强表面生物活性的植入物。由微弧氧化(MAO)产生的具有大孔结构的涂层具有优点,例如与基材的强粘合性和优异的抗磨损和耐腐蚀性。中孔结构含有2-50nm大小的孔隙,可赋予生物材料增强骨形成的能力,并可装载多种药物。因此,在这项研究中,我们旨在评估大孔和介孔结构使用分级宏/中孔结构修饰钛种植体表面的影响。

研究探究了SaOS-2骨肉瘤细胞在宏观/介孔结构上的行为,包括初始粘附、增殖、碱性磷酸酶(ALP)活性和胶原分泌。结果显示,与胎牛血清(FBS)存在下抛光的光滑底物和大孔表面相比,宏观/中孔表面上的细胞在孵育1、2和4小时后显示出最高的细胞数量和最大的铺展面积。然而,在FBS不存在的情况下,抛光基底与大孔结构和宏观/中孔结构上的细胞粘附没有明显差异。与其他表面相比,宏观/介孔结构上的细胞增殖增加。此外,在宏观/介孔结构上ALP活性和胶原分泌增强。

综上所述,该研究发现为植入物表面修饰领域中的宏/中孔结构的细胞反应提供了重要见解。

原始出处:

Zhang R, Elkhooly TA, et al., Effects of the hierarchical macro/mesoporous structure on the osteoblast-like cell response. J Biomed Mater Res A. 2018 Mar 9. doi: 10.1002/jbm.a.36387. [Epub ahead of print]

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    2019-02-09 sunylz
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    2018-03-15 zhaojie88
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