Indian J Urol:MicroRNA-21可作为预测非肌肉侵入性膀胱癌复发的分子标记

2017-10-25 AlexYang MedSci原创

非肌肉侵入性膀胱癌(NMIBC)的高复发率到目前为止还是一个巨大的挑战。 microRNA-21(miR-21)的超表达在膀胱肿瘤组织和正常粘膜的比较已经有所报道,并且miR-21能以与恶性肿瘤相关的磷酸酶和张力蛋白同源体基因(PTEN)为靶标。最近,有研究人员测试了是否miR-21在膀胱粘膜中的水平可以预测肿瘤复发。在一个前瞻性的群体研究中,研究人员在经尿道膀胱肿瘤切除术中从BC病人中获取了肿瘤

非肌肉侵入性膀胱癌(NMIBC)的高复发率到目前为止还是一个巨大的挑战。 microRNA-21(miR-21)的超表达在膀胱肿瘤组织和正常粘膜的比较已经有所报道,并且miR-21能以与恶性肿瘤相关的磷酸酶和张力蛋白同源体基因(PTEN)为靶标。最近,有研究人员测试了是否miR-21在膀胱粘膜中的水平可以预测肿瘤复发。在一个前瞻性的群体研究中,研究人员在经尿道膀胱肿瘤切除术中从BC病人中获取了肿瘤组织和正常膀胱粘膜(NBM),还从良性前列腺增生病人中获取了年龄和种族相匹配的NBM作为对照,并利用定量反转录PCR分析了miR-21的表达。研究人员对病人进行了为期4年的肿瘤复发跟踪调查,并利用卡普兰-迈耶曲线记录和计算了术后复发情况。研究发现,在31名病人中,肿瘤组织与NBM相比,miR-21的表达上调(>4倍,P=0.003),并且PTEN水平显著降低(<7倍,P=0.001)。更多的是,miR-21倍数的变化在表现出复发的病人中要比不复发病人的显著更高(>3倍,P=0.03)。进一步研究表明,卡普兰-迈耶曲线展示了miR-21的超表达与更短的复发时间相关,并且伴随着更高的累积风险。最后

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    2018-08-25 仁心济世
  4. 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  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Oct 25 22:33:06 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255941, encodeId=44f425594163, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Oct 25 21:43:55 CST 2017, time=2017-10-25, status=1, ipAttribution=)]
    2018-08-19 xjy02
  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Oct 25 22:33:06 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255941, encodeId=44f425594163, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Oct 25 21:43:55 CST 2017, time=2017-10-25, status=1, ipAttribution=)]
    2017-11-01 天涯183

    非常好的文章.学习了

    0

  7. 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createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Oct 27 12:19:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469092, encodeId=35711469092b7, content=<a href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Fri Oct 27 12:19:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255960, encodeId=2ea92559606a, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Oct 25 22:33:06 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255941, encodeId=44f425594163, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Oct 25 21:43:55 CST 2017, time=2017-10-25, status=1, ipAttribution=)]
    2017-10-27 zhouqu_8
  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Oct 25 22:33:06 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255941, encodeId=44f425594163, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Oct 25 21:43:55 CST 2017, time=2017-10-25, status=1, ipAttribution=)]
    2017-10-27 xiaogang319
  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Oct 25 22:33:06 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255941, encodeId=44f425594163, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Oct 25 21:43:55 CST 2017, time=2017-10-25, status=1, ipAttribution=)]
    2017-10-25 三生有幸9135

    学习一下谢谢分享

    0

  10. 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    2017-10-25 天涯183

    非常好的文章.学习了

    0

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