J Clin Periodontol:牙周治疗对超重患者脂肪因子生物标志物的影响

2020-06-25 MedSci原创 MedSci原创

本研究旨在评价超重或正常体重的牙周炎患者非手术牙周治疗27.5个月后炎症相关的生物标志物,血清类粘蛋白(ORM)、高敏C反应蛋白(hsCRP)、chemerin和视黄醇结合蛋白4(RBP4)水平的变化

本研究旨在评价超重或正常体重的牙周炎患者非手术牙周治疗27.5个月后炎症相关的生物标志物,血清类粘蛋白(ORM)、高敏C反应蛋白(hsCRP)、chemerin和视黄醇结合蛋白4(RBP4)水平的变化。

该分析包括ABPARO试验的患者。研究纳入了BMI指数高(≥28 kg/m2)或中等(21-24 kg/m2)的未治疗牙周炎的患者。在每个方案中,随机选取80名患者,并对BMI组、性别和治疗组(抗生素/安慰剂)进行分层,结果有40名超重和正常体重的患者。患者每隔3个月接受一次非手术牙周治疗和维护。基线和初始治疗后27.5个月取血用于检测ORM、hsCRP、chemerin和RBP4水平。

结果发现,在27.5个月,超重组(ORM:P = .001,hsCRP:P = .004)和正常体重患者(ORM:P = .007,hsCRP:P < .001)的ORM和hsCRP明显下降。Chemerin在超重组中下降(p = .048),RBP4水平保持稳定。

因此,非手术牙周治疗可以降低牙周炎患者全身炎症相关生物标志物,并且在超重患者中比正常体重患者中更为明显。

原文出处:

Johannes Matern,Effect of periodontal therapy on adipokine biomarkers in overweigh. Journal of clinical Periodontology, 2020 June, doi: 10.1111/jcpe.13288

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    2020-10-02 zutt
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    2020-08-07 feather89
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