Janssen启动了Crohn''s药物Tremfya的PhII / III期计划

2018-07-11 MedSci MedSci原创

Janssen启动了一项评估克罗恩病Tremfya的II / III期计划。GALAXY计划将包括一项II期研究(GALAXY 1),随后进行两项III期研究(GALAXI 2和GALAXI 3),预计将招募约2,000名患者。Tremfya(guselkumab)的安全性和有效性将在患有中度至重度活动形式的克罗恩病的患者中进行评估,克罗恩病是一种无法治愈的炎症性肠病。Tremfya是由Janss



Janssen启动了一项评估克罗恩病Tremfya的II / III期计划。

GALAXY计划将包括一项II期研究(GALAXY 1),随后进行两项III期研究(GALAXI 2和GALAXI 3),预计将招募约2,000名患者。

Tremfya(guselkumab)的安全性和有效性将在患有中度至重度活动形式的克罗恩病的患者中进行评估,克罗恩病是一种无法治愈的炎症性肠病

Tremfya是由Janssen开发的完全人类抗IL-23单克隆抗体,利用MorphoSys专有的HuCAL抗体技术生成,该技术已在欧洲和美国被批准用于治疗牛皮癣。

"我们非常高兴我们的被许可人Janssen已开始在克罗恩病中开展关键的II / III期开发计划,克罗恩病是一种严重的疾病,尽管有一些有效的治疗方法,但仍存在严重的未满足需求。如果成功,这可能会导致Tremfya的治疗范围进一步扩大,"MorphoSys首席科学官Markus Enzelberger博士指出。
进入第二阶段/第三阶段试验,MorphoSys会收到两笔来自Janssen的的未公开的里程碑付款。


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    2018-08-13 tongyongming
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channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Mon Dec 24 11:07:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857682, encodeId=474b185e6824a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 26 23:07:00 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331402, encodeId=5441331402ed, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Jul 13 23:06:06 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256413, encodeId=0aa31256413eb, content=<a href='/topic/show?id=af4c1e797f8' target=_blank style='color:#2F92EE;'>#tremfya#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17797, encryptionId=af4c1e797f8, topicName=tremfya)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Fri Jul 13 13:07:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527089, encodeId=4c41152e08917, content=<a 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331190, encodeId=1c2f331190d2, content=学习一下.很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Jul 13 00:31:31 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-12-24 juliusluan78
  5. 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topicName=REM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78bc36479935, createdName=tongyongming, createdTime=Mon Aug 13 11:07:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030242, encodeId=84c5203024264, content=<a href='/topic/show?id=28cb526232' target=_blank style='color:#2F92EE;'>#Crohn#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5262, encryptionId=28cb526232, topicName=Crohn)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Tue Feb 19 06:07:00 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916025, encodeId=ab011916025c1, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Mon Dec 24 11:07:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857682, encodeId=474b185e6824a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 26 23:07:00 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331402, encodeId=5441331402ed, content=不错的文章值得拥有哦, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331190, encodeId=1c2f331190d2, content=学习一下.很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Jul 13 00:31:31 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
  6. 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topicName=REM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78bc36479935, createdName=tongyongming, createdTime=Mon Aug 13 11:07:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030242, encodeId=84c5203024264, content=<a href='/topic/show?id=28cb526232' target=_blank style='color:#2F92EE;'>#Crohn#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5262, encryptionId=28cb526232, topicName=Crohn)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Tue Feb 19 06:07:00 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916025, encodeId=ab011916025c1, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Mon Dec 24 11:07:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857682, encodeId=474b185e6824a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 26 23:07:00 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331402, encodeId=5441331402ed, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Jul 13 23:06:06 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256413, encodeId=0aa31256413eb, content=<a href='/topic/show?id=af4c1e797f8' target=_blank style='color:#2F92EE;'>#tremfya#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17797, encryptionId=af4c1e797f8, topicName=tremfya)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Fri Jul 13 13:07:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527089, encodeId=4c41152e08917, content=<a href='/topic/show?id=ad4410248b5' target=_blank style='color:#2F92EE;'>#Janssen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10248, encryptionId=ad4410248b5, topicName=Janssen)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ca11798386, createdName=zhang92564, createdTime=Fri Jul 13 13:07:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594527, encodeId=ff1c159452e04, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Jul 13 13:07:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331190, encodeId=1c2f331190d2, content=学习一下.很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Jul 13 00:31:31 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

  7. 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channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Mon Dec 24 11:07:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857682, encodeId=474b185e6824a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 26 23:07:00 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331402, encodeId=5441331402ed, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Jul 13 23:06:06 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256413, encodeId=0aa31256413eb, content=<a href='/topic/show?id=af4c1e797f8' target=_blank style='color:#2F92EE;'>#tremfya#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17797, encryptionId=af4c1e797f8, topicName=tremfya)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Fri Jul 13 13:07:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527089, encodeId=4c41152e08917, content=<a href='/topic/show?id=ad4410248b5' target=_blank style='color:#2F92EE;'>#Janssen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10248, encryptionId=ad4410248b5, topicName=Janssen)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ca11798386, createdName=zhang92564, createdTime=Fri Jul 13 13:07:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594527, encodeId=ff1c159452e04, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Jul 13 13:07:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331190, encodeId=1c2f331190d2, content=学习一下.很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Jul 13 00:31:31 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 Luyuxie_9
  8. 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  9. 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    2018-07-13 1771ae4158m

    学习一下.很不错

    0

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