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JACC：脂蛋白（a）浓度与心血管疾病和2型糖尿病发生明显相关

2019-12-10 不详 MedSci原创

心血管脂蛋白糖尿病
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脂蛋白（a）是一个常见的心血管危险因素，且无已知的治疗策略，低水平的LP(a)与2型糖尿病（T2D）的发生相关。本研究的目的旨在探究LP(a)的摩尔浓度或载脂蛋白(a)的大小与心血管的相关性，以及Lp（a）与T2D风险之间是否存在因果关系。本研究是一个包含143087名冰岛人群的病例对照研究，包括17715名冠心病患者和8734名T2D患者，分析结果发现，LP(a)的摩尔浓度与冠心病、外周动脉疾病

脂蛋白（a）是一个常见的心血管危险因素，且无已知的治疗策略，低水平的LP(a)与2型糖尿病（T2D）的发生相关。本研究的目的旨在探究LP(a)的摩尔浓度或载脂蛋白(a)的大小与心血管的相关性，以及Lp（a）与T2D风险之间是否存在因果关系。

本研究是一个包含143087名冰岛人群的病例对照研究，包括17715名冠心病患者和8734名T2D患者，分析结果发现，LP(a)的摩尔浓度与冠心病、外周动脉疾病、主动脉瓣狭窄、心衰和寿命呈剂量相关性，LP(a)的摩尔浓度可以完全解释冠心病的发生风险，而与载脂蛋白(a)的大小无明显相关性。

研究结果显示，脂蛋白（a）的摩尔浓度是心血管疾病的独立危险因素，低水平LP(a)与2型糖尿病的发生相关。

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    2019-12-19 hbwxf

    #JACC#

    0

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    2020-01-02 哎呀哎呀

    学习

    0

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    2019-12-27 哎呀哎呀

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1854610, encodeId=652e1854610f7, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Dec 19 14:10:00 CST 2019, time=2019-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377717, encodeId=78133e771701, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Jan 02 22:19:26 CST 2020, time=2020-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377484, encodeId=aa333e74842f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Fri Dec 27 10:59:19 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377433, encodeId=b6d53e743384, content=谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Dec 26 00:30:01 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377422, encodeId=6c4e3e74225d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Wed Dec 25 20:02:59 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377184, encodeId=c1c73e718497, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Fri Dec 20 00:06:59 CST 2019, time=2019-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377150, encodeId=e9933e71507a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Dec 19 09:31:23 CST 2019, time=2019-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377095, encodeId=35613e709583, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Wed Dec 18 00:01:37 CST 2019, time=2019-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377054, encodeId=d1633e7054e8, content=糖脂一定是相关影响因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Dec 17 06:39:50 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377053, encodeId=d6c33e7053f3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Tue Dec 17 06:30:47 CST 2019, time=2019-12-17, status=1, ipAttribution=)]
    2019-12-26 哎呀哎呀

    谢谢了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1854610, encodeId=652e1854610f7, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Dec 19 14:10:00 CST 2019, time=2019-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377717, encodeId=78133e771701, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Jan 02 22:19:26 CST 2020, time=2020-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377484, encodeId=aa333e74842f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Fri Dec 27 10:59:19 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377433, encodeId=b6d53e743384, content=谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Dec 26 00:30:01 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377422, encodeId=6c4e3e74225d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Wed Dec 25 20:02:59 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377184, encodeId=c1c73e718497, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Fri Dec 20 00:06:59 CST 2019, time=2019-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377150, encodeId=e9933e71507a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Dec 19 09:31:23 CST 2019, time=2019-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377095, encodeId=35613e709583, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Wed Dec 18 00:01:37 CST 2019, time=2019-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377054, encodeId=d1633e7054e8, content=糖脂一定是相关影响因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Dec 17 06:39:50 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377053, encodeId=d6c33e7053f3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Tue Dec 17 06:30:47 CST 2019, time=2019-12-17, status=1, ipAttribution=)]
    2019-12-25 哎呀哎呀

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1854610, encodeId=652e1854610f7, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Dec 19 14:10:00 CST 2019, time=2019-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377717, encodeId=78133e771701, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Jan 02 22:19:26 CST 2020, time=2020-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377484, encodeId=aa333e74842f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Fri Dec 27 10:59:19 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377433, encodeId=b6d53e743384, content=谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Dec 26 00:30:01 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377422, encodeId=6c4e3e74225d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Wed Dec 25 20:02:59 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377184, encodeId=c1c73e718497, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Fri Dec 20 00:06:59 CST 2019, time=2019-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377150, encodeId=e9933e71507a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Thu Dec 19 09:31:23 CST 2019, time=2019-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377095, encodeId=35613e709583, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Wed Dec 18 00:01:37 CST 2019, time=2019-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377054, encodeId=d1633e7054e8, content=糖脂一定是相关影响因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Dec 17 06:39:50 CST 2019, time=2019-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377053, encodeId=d6c33e7053f3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/10/0a4ba92996a8d65f5ad5fbe054c334b6.jpg, createdBy=fa4c5244095, createdName=哎呀哎呀, createdTime=Tue Dec 17 06:30:47 CST 2019, time=2019-12-17, status=1, ipAttribution=)]
    2019-12-20 哎呀哎呀

    好

    0

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    2019-12-19 哎呀哎呀

    学习了

    0

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    2019-12-18 哎呀哎呀

    学习了

    0

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    2019-12-17 130****4638

    糖脂一定是相关影响因素。

    0

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    2019-12-17 哎呀哎呀

    学习了

    0

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